Seroatlas · Human Serome Atlas

TRIM29

Tripartite motif-containing protein 29

Also known as: ATDC, FLJ36085, TRI29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14134
Gene: TRIM29
Ensembl: ENSG00000137699
Chromosome: 11
Canonical length: 588 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Intermediate filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q14134|TRIM29
     1  MEAADASRSN GSSPEARDAR SPSGPSGSLE NGTKADGKDA KTTNGHGGEA AEGKSLGSAL
    61  KPGEGRSALF AGNEWRRPII QFVESGDDKN SNYFSMDSME GKRSPYAGLQ LGAAKKPPVT
   121  FAEKGELRKS IFSESRKPTV SIMEPGETRR NSYPRADTGL FSRSKSGSEE VLCDSCIGNK
   181  QKAVKSCLVC QASFCELHLK PHLEGAAFRD HQLLEPIRDF EARKCPVHGK TMELFCQTDQ
   241  TCICYLCMFQ EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDEAE KWQKEKDRIK
   301  SFTTNEKAIL EQNFRDLVRD LEKQKEEVRA ALEQREQDAV DQVKVIMDAL DERAKVLHED
   361  KQTREQLHSI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL EGEGLGQSLG NFKDDLLNVC
   421  MRHVEKMCKA DLSRNFIERN HMENGGDHRY VNNYTNSFGG EWSAPDTMKR YSMYLTPKGG
   481  VRTSYQPSSP GRFTKETTQK NFNNLYGTKG NYTSRVWEYS SSIQNSDNDL PVVQGSSSFS
   541  LKGYPSLMRS QSPKAQPQTW KSGKQTMLSH YRPFYVNKGN GIGSNEAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 720 nTPM

Expression across tissuesHPA

Tissue

skin: 720 nTPM
esophagus: 700 nTPM
vagina: 362 nTPM
cervix: 250 nTPM
salivary gland: 174 nTPM
tonsil: 100 nTPM

Single-cell type

esophageal apical cells: 1,446 nCPM
esophageal suprabasal cells: 1,242 nCPM
suprabasal keratinocytes: 912 nCPM
ocular epithelial cells: 820 nCPM
esophageal basal cells: 675 nCPM
basal keratinocytes: 435 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 6.9 nTPM
medulla oblongata: 5.2 nTPM
pons: 5.1 nTPM
choroid plexus: 4.7 nTPM
white matter: 2.5 nTPM
midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM29 as an antibody target. Whether an autoantibody or antibody against TRIM29 could matter depends on whether native TRIM29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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