Seroatlas · Human Serome Atlas

TRIM44

Tripartite motif-containing protein 44

Also known as: DIPB, MC7, TRI44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DX7
Gene
TRIM44
Ensembl
ENSG00000166326
Chromosome
11
Canonical length
344 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q96DX7|TRIM44
     1  MASGVGAAFE ELPHDGTCDE CEPDEAPGAE EVCRECGFCY CRRHAEAHRQ KFLSHHLAEY
    61  VHGSQAWTPP ADGEGAGKEE AEVKVEQERE IESEAGEESE SEEESESEEE SETEEESEDE
   121  SDEESEEDSE EEMEDEQESE AEEDNQEEGE SEAEGETEAE SEFDPEIEME AERVAKRKCP
   181  DHGLDLSTYC QEDRQLICVL CPVIGAHQGH QLSTLDEAFE ELRSKDSGGL KAAMIELVER
   241  LKFKSSDPKV TRDQMKMFIQ QEFKKVQKVI ADEEQKALHL VDIQEAMATA HVTEILADIQ
   301  SHMDRLMTQM AQAKEQLDTS NESAEPKAEG DEEGPSGASE EEDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • retina: 25 nTPM
  • cerebellum: 24 nTPM
  • cerebral cortex: 17 nTPM
  • spinal cord: 17 nTPM
  • kidney: 17 nTPM
  • midbrain: 16 nTPM

Single-cell type

  • lactotrophs: 287 nCPM
  • somatotrophs: 266 nCPM
  • thyrotrophs: 258 nCPM
  • retinal bipolar cells: 256 nCPM
  • retinal amacrine cells: 246 nCPM
  • pituicytes/fscs: 236 nCPM

Immune cell

  • plasmacytoid DC: 1.8 nTPM
  • naive B-cell: 1.5 nTPM
  • non-classical monocyte: 1.5 nTPM
  • intermediate monocyte: 1.2 nTPM
  • naive CD8 T-cell: 1.2 nTPM
  • NK-cell: 1.2 nTPM

Brain region

  • cerebral cortex: 49 nTPM
  • white matter: 43 nTPM
  • spinal cord: 42 nTPM
  • cerebellum: 42 nTPM
  • thalamus: 41 nTPM
  • hypothalamus: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM44.

Disease | AllUniProt

Conditions TRIM44 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.05
gnomAD missense Z
1.07
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM44 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM44 as an antibody target. Whether an autoantibody or antibody against TRIM44 could matter depends on whether native TRIM44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM44. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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