Seroatlas · Human Serome Atlas

TRIM66

Tripartite motif-containing protein 66

Also known as: TRI66_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15016
Gene
TRIM66
Canonical length
1351 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

No narrative summary is available for TRIM66 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1351 residues, UniProt reviewed canonical sequence.

>O15016|TRIM66
     1  MSFMGLPLAG QKHCPKSGQM EAMVMTCSLC HQDLPGMGSH LLSCQHLLRK DCFQGLIQEL
    61  GQIAKAHETV ADELISCPGC ERVYLTRDVT EHFFLHCVPT EQPKMARNCS ECKEKRAAHI
   121  LCTYCNRWLC SSCTEEHRHS PVPGGPFFPR AQKGSPGVNG GPGDFTLYCP LHTQEVLKLF
   181  CETCDMLTCH SCLVVEHKEH RCRHVEEVLQ NQRMLLEGVT TQVAHKKSSL QTSAKQIEDR
   241  IFEVKHQHRK VENQIKMAKM VLMNELNKQA NGLIEELEGI TNERKRKLEQ QLQSIMVLNR
   301  QFEHVQNFIN WAVCSKTSVP FLFSKELIVF QMQRLLETSC NTDPGSPWSI RFTWEPNFWT
   361  KQLASLGCIT TEGGQMSRAD APAYGGLQGS SPFYQSHQSP VAQQEALSHP SHKFQSPAVC
   421  SSSVCCSHCS PVSPSLKGQV PPPSIHPAHS FRQPPEMVPQ QLGSLQCSAL LPREKELACS
   481  PHPPKLLQPW LETQPPVEQE STSQRLGQQL TSQPVCIVPP QDVQQGAHAQ PTLQTPSIQV
   541  QFGHHQKLKL SHFQQQPQQQ LPPPPPPLPH PPPPLPPPPQ QPHPPLPPSQ HLASSQHESP
   601  PGPACSQNMD IMHHKFELEE MQKDLELLLQ AQQPSLQLSQ TKSPQHLQQT IVGQINYIVR
   661  QPAPVQSQSQ EETLQATDEP PASQGSKPAL PLDKNTAAAL PQASGEETPL SVPPVDSTIQ
   721  HSSPNVVRKH STSLSIMGFS NTLEMELSST RLERPLEPQI QSVSNLTAGA PQAVPSLLSA
   781  PPKMVSSLTS VQNQAMPSLT TSHLQTVPSL VHSTFQSMPN LISDSPQAMA SLASDHPQAG
   841  PSLMSGHTQA VPSLATCPLQ SIPPVSDMQP ETGSSSSSGR TSGSLCPRDG ADPSLENALC
   901  KMESEDSTRF TDLLGQGPIV PGLDAPKDLA IPSELEEPIN LSVKKPPLAP VVSTSTALQQ
   961  YQNPKECENF EQGALELDAK ENQSIRAFNS EHKIPYVRLE RLKICAASSG EMPVFKLKPQ
  1021  KNDQDGSFLL IIECGTESSS MSIKVSQDRL SEATQAPGLE GRKVTVTSLA GQRPPEVEGT
  1081  SPEEHRLIPR TPGAKKGPPA PIENEDFCAV CLNGGELLCC DRCPKVFHLS CHVPALLSFP
  1141  GGEWVCTLCR SLTQPEMEYD CENACYNQPG MRASPGLSMY DQKKCEKLVL SLCCNNLSLP
  1201  FHEPVSPLAR HYYQIIKRPM DLSIIRRKLQ KKDPAHYTTP EEVVSDVRLM FWNCAKFNYP
  1261  DSEVAEAGRC LEVFFEGWLK EIYPEKRFAQ PRQEDSDSEE VSSESGCSTP QGFPWPPYMQ
  1321  EGIQPKRRRR HMENERAKRM SFRLANSISQ V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM66 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • skin: 9 nTPM
  • epididymis: 5.8 nTPM
  • lymph node: 4.2 nTPM
  • tonsil: 4.2 nTPM
  • thyroid gland: 4.1 nTPM

Single-cell type

  • early spermatids: 193 nCPM
  • somatotrophs: 98 nCPM
  • sertoli cells: 98 nCPM
  • adrenal cortex cells: 93 nCPM
  • choroid plexus epithelial cells: 88 nCPM
  • ependymal cells: 87 nCPM

Immune cell

  • plasmacytoid DC: 0.8 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • NK-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • myeloid DC: 0.5 nTPM
  • gdT-cell: 0.4 nTPM

Brain region

  • basal ganglia: 14 nTPM
  • hypothalamus: 13 nTPM
  • midbrain: 13 nTPM
  • thalamus: 12 nTPM
  • medulla oblongata: 11 nTPM
  • choroid plexus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
1.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM66 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM66 as an antibody target. Whether an autoantibody or antibody against TRIM66 could matter depends on whether native TRIM66 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM66 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM66 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM66. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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