TRIM46

Protein identityUniProt · HPA

UniProt accession

Q7Z4K8

Gene

TRIM46

Ensembl

ENSG00000163462

Chromosome

1

Canonical length

759 aa

Protein class

Predicted intracellular proteins

Subcellular location

Microtubule ends,Cytokinetic bridge,Mitotic spindle,Primary cilium transition zone,Centrosome

OverviewNCBI Gene

This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of cancer cells including lung and breast cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]

Canonical amino-acid sequenceUniProt

759 residues, UniProt reviewed canonical sequence.

>Q7Z4K8|TRIM46
     1  MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH NVCQACAREV
    61  LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD RLDRLLKSGF GTYPGRKRGA
   121  LHPQVIMFPC PACQGDVELG ERGLAGLFRN LTLERVVERY RQSVSVGGAI LCQLCKPPPL
   181  EATKGCTECR ATFCNECFKL FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT
   241  CQRLVCQLCR VRRTHSGHKI TPVLSAYQAL KDKLTKSLTY ILGNQDTVQT QICELEEAVR
   301  HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLARLSAQI QEHRSLLDGS
   361  GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR PAASSSFRHC QLDVGREMKL
   421  LTELNFLRVP EAPVIDTQRT FAYDQIFLCW RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW
   481  QRREEVRGTS ALLENPDTGS VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDSRWG
   541  ASRERLAISK DQRAVRSVPG LPLLLAADRL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP
   601  ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDATVEASPP FAFLTIGMGK
   661  ILLGSGASSN AGLTGRDGPT AGCTVPLPPR LGICLDYERG RVSFLDAVSF RGLLECPLDC
   721  SGPVCPAFCF IGGGAVQLQE PVGTKPERKV TIGGFAKLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

22 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for TRIM46 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

3.25

DepMap mean gene effect

-0.27

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterograde synaptic vesicle transport
• axonogenesis
• microtubule bundle formation
• negative regulation of axon extension
• neuron migration
• positive regulation of anterograde dense core granule transport
• protein localization to axon
• regulation of protein localization

Molecular functions

• zinc ion binding

Cellular components

• axon cytoplasm
• axon initial segment
• cytoskeleton
• main axon
• proximal neuron projection

Protein domainsUniProt · Pfam · InterPro

• B-box-type zinc finger
• Zinc finger, RING-type
• B30.2/SPRY domain
• Fibronectin type III
• Zinc finger, RING/FYVE/PHD-type
• Concanavalin A-like lectin/glucanase domain superfamily
• Immunoglobulin-like fold
• COS domain
• Zinc finger, RING-type, conserved site
• Zinc finger, RING-type, eukaryotic
• Fibronectin type III superfamily
• Midline-1, COS domain
• B30.2/SPRY domain superfamily
• E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins
• B-box zinc finger
• RING-type zinc-finger
• TRIM C-terminal subgroup One Signature domain
• TRIM46, PRY/SPRY domain

KeywordsUniProt

• Cell projection
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Metal-binding
• Phosphoprotein
• Repeat
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of TRIM46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TUBA4A
• TUBB3