Seroatlas · Human Serome Atlas

TRIM56

E3 ubiquitin-protein ligase TRIM56

Also known as: RNF109, TRI56_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRZ2
Gene
TRIM56
Ensembl
ENSG00000169871
Chromosome
7
Canonical length
755 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in defense response to virus; positive regulation of signal transduction; and protein monoubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

755 residues, UniProt reviewed canonical sequence.

>Q9BRZ2|TRIM56
     1  MVSHGSSPSL LEALSSDFLA CKICLEQLRA PKTLPCLHTY CQDCLAQLAD GGRVRCPECR
    61  ETVPVPPEGV ASFKTNFFVN GLLDLVKARA CGDLRAGKPA CALCPLVGGT STGGPATARC
   121  LDCADDLCQA CADGHRCTRQ THTHRVVDLV GYRAGWYDEE ARERQAAQCP QHPGEALRFL
   181  CQPCSQLLCR ECRLDPHLDH PCLPLAEAVR ARRPGLEGLL AGVDNNLVEL EAARRVEKEA
   241  LARLREQAAR VGTQVEEAAE GVLRALLAQK QEVLGQLRAH VEAAEEAARE RLAELEGREQ
   301  VARAAAAFAR RVLSLGREAE ILSLEGAIAQ RLRQLQGCPW APGPAPCLLP QLELHPGLLD
   361  KNCHLLRLSF EEQQPQKDGG KDGAGTQGGE ESQSRREDEP KTERQGGVQP QAGDGAQTPK
   421  EEKAQTTREE GAQTLEEDRA QTPHEDGGPQ PHRGGRPNKK KKFKGRLKSI SREPSPALGP
   481  NLDGSGLLPR PIFYCSFPTR MPGDKRSPRI TGLCPFGPRE ILVADEQNRA LKRFSLNGDY
   541  KGTVPVPEGC SPCSVAALQS AVAFSASARL YLINPNGEVQ WRRALSLSQA SHAVAALPSG
   601  DRVAVSVAGH VEVYNMEGSL ATRFIPGGKA SRGLRALVFL TTSPQGHFVG SDWQQNSVVI
   661  CDGLGQVVGE YKGPGLHGCQ PGSVSVDKKG YIFLTLREVN KVVILDPKGS LLGDFLTAYH
   721  GLEKPRVTTM VDGRYLVVSL SNGTIHIFRV RSPDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM56 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 20 nTPM
  • ovary: 17 nTPM
  • lung: 17 nTPM
  • blood vessel: 15 nTPM
  • skin: 15 nTPM
  • lymph node: 14 nTPM

Single-cell type

  • leydig cells: 138 nCPM
  • respiratory ciliated cells: 132 nCPM
  • epididymal efferent duct ciliated cells: 117 nCPM
  • basal prostatic cells: 111 nCPM
  • epididymal basal cells: 108 nCPM
  • lacrimal acinar cells: 107 nCPM

Immune cell

  • NK-cell: 4.1 nTPM
  • neutrophil: 3.9 nTPM
  • gdT-cell: 1.8 nTPM
  • basophil: 1.7 nTPM
  • naive CD8 T-cell: 1.7 nTPM
  • naive B-cell: 1.6 nTPM

Brain region

  • medulla oblongata: 33 nTPM
  • white matter: 32 nTPM
  • thalamus: 28 nTPM
  • pons: 26 nTPM
  • midbrain: 26 nTPM
  • basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0
gnomAD missense Z
1.25
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM56 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM56 as an antibody target. Whether an autoantibody or antibody against TRIM56 could matter depends on whether native TRIM56 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM56 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM56 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM56. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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