Seroatlas · Human Serome Atlas

TRIM73

Tripartite motif-containing protein 73

Also known as: TRI73_HUMAN, TRIM50B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UV7
Gene
TRIM73
Ensembl
ENSG00000178809
Chromosome
7
Canonical length
250 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q86UV7|TRIM73
     1  MAWQVSLLEL EDRLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV
    61  DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH
   121  PVTPVSTVCS RMKEELAALF SELKQEQKKV DELIAKLVKN RTRIVNESDV FSWVIRREFQ
   181  ELRHPVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF
   241  IWKFHSMASR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 18 nTPM
  • duodenum: 14 nTPM
  • pancreas: 13 nTPM
  • small intestine: 11 nTPM
  • testis: 11 nTPM
  • salivary gland: 10 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 42 nCPM
  • parietal cells: 35 nCPM
  • distal convoluted tubule cells: 27 nCPM
  • proximal tubule cells: 22 nCPM
  • loop of henle epithelial cells: 22 nCPM
  • renal collecting duct principal cells: 20 nCPM

Immune cell

  • plasmacytoid DC: 1 nTPM
  • naive B-cell: 0.9 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • memory B-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • gdT-cell: 0.7 nTPM

Brain region

  • cerebellum: 20 nTPM
  • choroid plexus: 16 nTPM
  • white matter: 14 nTPM
  • cerebral cortex: 14 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
0.61

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM73 as an antibody target. Whether an autoantibody or antibody against TRIM73 could matter depends on whether native TRIM73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM73. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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