Seroatlas · Human Serome Atlas

TRIM3

Tripartite motif-containing protein 3

Also known as: BERP, HAC1, RNF22, RNF97, TRIM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75382
Gene
TRIM3
Ensembl
ENSG00000110171
Chromosome
11
Canonical length
744 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria
Quaternary structure
Homooligomer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

744 residues, UniProt reviewed canonical sequence.

>O75382|TRIM3
     1  MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI PAQSLTLSCP
    61  VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSVVAG RPLSCPNHEG
   121  KTMEFYCEAC ETAMCGECRA GEHREHGTVL LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI
   181  ALVGGISQQL QERKAEALAQ ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT
   241  LRQGQEHIGS SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL
   301  EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK DGRLVRTGSA
   361  ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL SVLLYGQPVR GSPFRVRALR
   421  PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV RRPSSMYSTG GKRKDNPIED ELVFRVGSRG
   481  REKGEFTNLQ GVSAASSGRI VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA
   541  VDTNGDIIVA DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF
   601  TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS ADGEFLFKFG
   661  SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG SFLSYINTSA EPLYGPQGLA
   721  LTSDGHVVVA DAGNHCFKAY RYLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 49 nTPM
  • duodenum: 16 nTPM
  • cerebral cortex: 16 nTPM
  • blood vessel: 15 nTPM
  • small intestine: 14 nTPM
  • endometrium: 13 nTPM

Single-cell type

  • enterocytes: 37 nCPM
  • goblet cells: 27 nCPM
  • retinal ganglion cells: 23 nCPM
  • rod photoreceptor cells: 23 nCPM
  • brain excitatory neurons: 23 nCPM
  • colonocytes: 21 nCPM

Immune cell

  • myeloid DC: 1.2 nTPM
  • classical monocyte: 1 nTPM
  • intermediate monocyte: 0.9 nTPM
  • NK-cell: 0.6 nTPM
  • eosinophil: 0.5 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • cerebellum: 39 nTPM
  • pons: 35 nTPM
  • cerebral cortex: 30 nTPM
  • basal ganglia: 29 nTPM
  • thalamus: 28 nTPM
  • white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
3.71
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM3 as an antibody target. Whether an autoantibody or antibody against TRIM3 could matter depends on whether native TRIM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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