Seroatlas · Human Serome Atlas

RNF207

RING finger protein 207

Also known as: C1orf188, FLJ32096, FLJ46380, RN207_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRF8
Gene: RNF207
Ensembl: ENSG00000158286
Chromosome: 1
Canonical length: 634 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables Hsp70 protein binding activity and transmembrane transporter binding activity. Involved in positive regulation of gene expression. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q6ZRF8|RNF207
     1  MSGAIFGPLE GPSSLDAPSI HPLVCPLCHV QYERPCLLDC FHDFCAGCLR GRATDGRLTC
    61  PLCQHQTVLK GPSGLPPVDR LLQFLVDSSG DGVEAVRCAN CDLECSEQDV ETTYFCNTCG
   121  QPLCARCRDE THRARMFARH DIVALGQRSR DVPQKCTLHA EPYLLFSTDK KLLLCIRCFR
   181  DMQKESRAHC VDLESAYVQG CERLEQAVLA VKALQTATRE AIALLQAMVE EVRHSAAEEE
   241  DAIHALFGSM QDRLAERKAL LLQAVQSQYE EKDKAFKEQL SHLATLLPTL QVHLVICSSF
   301  LSLANKAEFL DLGYELMERL QGIVTRPHHL RPIQSSKIAS DHRAEFARCL EPLLLLGPRR
   361  VAAAASGANT LAGGLGPKAL TGPHCPSPVG KMSGSPVQKP TLHRSISTKV LLAEGENTPF
   421  AEHCRHYEDS YRHLQAEMQS LKDQVQELHR DLTKHHSLIK AEIMGDVLHK SLQLDVQIAS
   481  EHASLEGMRV VFQEIWEEAY QRVANEQEIY EAQLHDLLQL RQENAYLTTI TKQITPYVRS
   541  IAKVKERLEP RFQAPVDEQS ESLQNTHDDS RNNAASARNN PGSVPEKREK TSEPKGNSWA
   601  PNGLSEEPLL KNMDHHRSKQ KNGGDVPTWR EHPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF207 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 33 nTPM
prostate: 12 nTPM
kidney: 9.9 nTPM
cervix: 8.9 nTPM
cerebellum: 8.2 nTPM
liver: 7.5 nTPM

Single-cell type

cardiomyocytes: 179 nCPM
salivary duct cells: 58 nCPM
respiratory basal cells: 40 nCPM
prostatic hillock cells: 37 nCPM
papillary tip epithelial cells: 33 nCPM
prostatic club cells: 32 nCPM

Immune cell

non-classical monocyte: 0.5 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 8.9 nTPM
cerebellum: 4.7 nTPM
pons: 4.3 nTPM
cerebral cortex: 4.1 nTPM
basal ganglia: 3.3 nTPM
amygdala: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF207.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Long QT syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of gene expression
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
regulation of cardiac muscle contraction
positive regulation of membrane repolarization during cardiac muscle cell action potential
regulation of heart looping

Molecular functions

Cellular components

perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF207 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF207 as an antibody target. Whether an autoantibody or antibody against RNF207 could matter depends on whether native RNF207 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF207 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF207 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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