Seroatlas · Human Serome Atlas

TRIM47

E3 ubiquitin-protein ligase TRIM47

Also known as: GOA, RNF100, TRI47_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LD4
Gene: TRIM47
Ensembl: ENSG00000132481
Chromosome: 17
Canonical length: 638 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>Q96LD4|TRIM47
     1  MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG AARCPLCQEP
    61  FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS APSALPSVPE PSAPCAPEPW
   121  PAGEEPVRCD ACPEGAALPA ALSCLSCLAS FCPAHLGPHE RSPALRGHRL VPPLRRLEES
   181  LCPRHLRPLE RYCRAERVCL CEACAAQEHR GHELVPLEQE RALQEAEQSK VLSAVEDRMD
   241  ELGAGIAQSR RTVALIKSAA VAERERVSRL FADAAAALQG FQTQVLGFIE EGEAAMLGRS
   301  QGDLRRQEEQ RSRLSRARQN LSQVPEADSV SFLQELLALR LALEDGCGPG PGPPRELSFT
   361  KSSQAVRAVR DMLAVACVNQ WEQLRGPGGN EDGPQKLDSE ADAEPQDLES TNLLESEAPR
   421  DYFLKFAYIV DLDSDTADKF LQLFGTKGVK RVLCPINYPL SPTRFTHCEQ VLGEGALDRG
   481  TYYWEVEIIE GWVSMGVMAE DFSPQEPYDR GRLGRNAHSC CLQWNGRSFS VWFHGLEAPL
   541  PHPFSPTVGV CLEYADRALA FYAVRDGKMS LLRRLKASRP RRGGIPASPI DPFQSRLDSH
   601  FAGLFTHRLK PAFFLESVDA HLQIGPLKKS CISVLKRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 46 nTPM
kidney: 37 nTPM
colon: 32 nTPM
spleen: 28 nTPM
heart muscle: 26 nTPM
blood vessel: 26 nTPM

Single-cell type

hofbauer cells: 107 nCPM
pancreatic duct cells: 88 nCPM
alveolar cells type 1: 65 nCPM
esophageal basal cells: 60 nCPM
smooth muscle cells: 56 nCPM
fallopian secretory cells: 55 nCPM

Immune cell

T-reg: 5.4 nTPM
MAIT T-cell: 4.6 nTPM
memory CD4 T-cell: 4 nTPM
naive CD4 T-cell: 2.6 nTPM
memory B-cell: 2.4 nTPM
memory CD8 T-cell: 2.2 nTPM

Brain region

thalamus: 66 nTPM
medulla oblongata: 58 nTPM
midbrain: 51 nTPM
white matter: 47 nTPM
basal ganglia: 47 nTPM
amygdala: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM47 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SATB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM47 as an antibody target. Whether an autoantibody or antibody against TRIM47 could matter depends on whether native TRIM47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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