Seroatlas · Human Serome Atlas

TRIM54

Tripartite motif-containing protein 54

Also known as: MURF, MURF-3, RNF30, TRI54_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYV2
Gene
TRIM54
Ensembl
ENSG00000138100
Chromosome
2
Canonical length
358 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q9BYV2|TRIM54
     1  MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP
    61  LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA
   121  EQHLMCEEHE EEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM
   181  LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE
   241  EKLQRVRGLI RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
   301  RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP EEERPDGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
570 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 570 nTPM
  • heart muscle: 205 nTPM
  • tongue: 166 nTPM
  • epididymis: 23 nTPM
  • testis: 22 nTPM
  • salivary gland: 9.6 nTPM

Single-cell type

  • myonuclei: 981 nCPM
  • thymic myoid cells: 204 nCPM
  • cardiomyocytes: 147 nCPM
  • podocytes: 42 nCPM
  • gastric progenitor cells: 40 nCPM
  • epididymal principal cells: 28 nCPM

Immune cell

  • NK-cell: 3.6 nTPM
  • MAIT T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • hippocampal formation: 5.4 nTPM
  • amygdala: 3.6 nTPM
  • white matter: 3.3 nTPM
  • cerebellum: 2.4 nTPM
  • basal ganglia: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM54 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM54 as an antibody target. Whether an autoantibody or antibody against TRIM54 could matter depends on whether native TRIM54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM54. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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