Seroatlas · Human Serome Atlas

TRIM63

E3 ubiquitin-protein ligase TRIM63

Also known as: IRF, MURF-1, RNF28, SMRZ, TRI63_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969Q1
Gene
TRIM63
Ensembl
ENSG00000158022
Chromosome
1
Canonical length
353 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q969Q1|TRIM63
     1  MDYKSSLIQD GNPMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT
    61  SRGSSVSMSG GRFRCPTCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP
   121  MCKEHEDEKI NIYCLTCEVP TCSMCKVFGI HKACEVAPLQ SVFQGQKTEL NNCISMLVAG
   181  NDRVQTIITQ LEDSRRVTKE NSHQVKEELS QKFDTLYAIL DEKKSELLQR ITQEQEKKLS
   241  FIEALIQQYQ EQLDKSTKLV ETAIQSLDEP GGATFLLTAK QLIKSIVEAS KGCQLGKTEQ
   301  GFENMDFFTL DLEHIADALR AIDFGTDEEE EEFIEEEDQE EEESTEGKEE GHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
1,847 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 1,847 nTPM
  • tongue: 362 nTPM
  • heart muscle: 225 nTPM
  • urinary bladder: 11 nTPM
  • salivary gland: 9.7 nTPM
  • esophagus: 6.7 nTPM

Single-cell type

  • thymic myoid cells: 631 nCPM
  • cardiomyocytes: 133 nCPM
  • myonuclei: 98 nCPM
  • melanocytes: 96 nCPM
  • mast cells: 83 nCPM
  • smooth muscle cells: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.5 nTPM
  • cerebral cortex: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • white matter: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • midbrain: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM63.

Disease | AllUniProt

Conditions TRIM63 is implicated in, by any mechanism.

  • Cardiomyopathy, familial hypertrophic, 31 (CMH31) MIM:621270

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0
gnomAD missense Z
-0.18
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM63 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM63 as an antibody target. Whether an autoantibody or antibody against TRIM63 could matter depends on whether native TRIM63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM63. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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