Seroatlas · Human Serome Atlas

TRIM37

E3 ubiquitin-protein ligase TRIM37

Also known as: KIAA0898, MUL, POB1, TEF3, TRI37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94972
Gene: TRIM37
Ensembl: ENSG00000108395
Chromosome: 17
Canonical length: 964 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

964 residues, UniProt reviewed canonical sequence.

>O94972|TRIM37
     1  MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL
    61  RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW
   121  GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL RRRLMELISL VQEVERNVEA VRNAKDERVR
   181  EIRNAVEMMI ARLDTQLKNK LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK
   241  SSEILMMFQQ VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP
   301  LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ SCNDPTKNII
   361  REFASDFEVG ECWGYNRFFR LDLLANEGYL NPQNDTVILR FQVRSPTFFQ KSRDQHWYIT
   421  QLEAAQTSYI QQINNLKERL TIELSRTQKS RDLSPPDNHL SPQNDDALET RAKKSACSDM
   481  LLEGGPTTAS VREAKEDEED EEKIQNEDYH HELSDGDLDL DLVYEDEVNQ LDGSSSSASS
   541  TATSNTEEND IDEETMSGEN DVEYNNMELE EGELMEDAAA AGPAGSSHGY VGSSSRISRR
   601  THLCSAATSS LLDIDPLILI HLLDLKDRSS IENLWGLQPR PPASLLQPTA SYSRKDKDQR
   661  KQQAMWRVPS DLKMLKRLKT QMAEVRCMKT DVKNTLSEIK SSSAASGDMQ TSLFSADQAA
   721  LAACGTENSG RLQDLGMELL AKSSVANCYI RNSTNKKSNS PKPARSSVAG SLSLRRAVDP
   781  GENSRSKGDC QTLSEGSPGS SQSGSRHSSP RALIHGSIGD ILPKTEDRQC KALDSDAVVV
   841  AVFSGLPAVE KRRKMVTLGA NAKGGHLEGL QMTDLENNSE TGELQPVLPE GASAAPEEGM
   901  SSDSDIECDT ENEEQEEHTS VGGFHDSFMV MTQPPDEDTH SSFPDGEQIG PEDLSFNTDE
   961  NSGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
cerebellum: 39 nTPM
cerebral cortex: 39 nTPM
retina: 30 nTPM
hypothalamus: 21 nTPM
basal ganglia: 19 nTPM

Single-cell type

cone photoreceptor cells: 226 nCPM
late primary spermatocytes: 193 nCPM
rod photoreceptor cells: 161 nCPM
sertoli cells: 148 nCPM
retinal ganglion cells: 139 nCPM
early primary spermatocytes: 131 nCPM

Immune cell

basophil: 31 nTPM
T-reg: 8.3 nTPM
gdT-cell: 7.2 nTPM
MAIT T-cell: 6.8 nTPM
naive CD8 T-cell: 5.4 nTPM
neutrophil: 5.4 nTPM

Brain region

cerebral cortex: 87 nTPM
cerebellum: 76 nTPM
pons: 73 nTPM
thalamus: 63 nTPM
white matter: 62 nTPM
medulla oblongata: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM37.

Disease | AllUniProt

Conditions TRIM37 is implicated in, by any mechanism.

Mulibrey nanism (MUL) MIM:253250

Disease | GeneticClinVar

113 pathogenic / likely-pathogenic of 866 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Mulibrey nanism syndrome
Inborn genetic diseases
See cases
TRIM37-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.57
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM37 as an antibody target. Whether an autoantibody or antibody against TRIM37 could matter depends on whether native TRIM37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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