Seroatlas · Human Serome Atlas

TRIM32

E3 ubiquitin-protein ligase TRIM32

Also known as: BBS11, HT2A, LGMD2H, TATIP, TRI32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13049
Gene
TRIM32
Ensembl
ENSG00000119401
Chromosome
9
Canonical length
653 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Intermediate filaments

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>Q13049|TRIM32
     1  MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK LLASSINGVR
    61  CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC RSCGRRLPRQ FCRSCGLVLC
   121  EPCREADHQP PGHCTLPVKE AAEERRRDFG EKLTRLRELM GELQRRKAAL EGVSKDLQAR
   181  YKAVLQEYGH EERRVQDELA RSRKFFTGSL AEVEKSNSQV VEEQSYLLNI AEVQAVSRCD
   241  YFLAKIKQAD VALLEETADE EEPELTASLP RELTLQDVEL LKVGHVGPLQ IGQAVKKPRT
   301  VNVEDSWAME ATASAASTSV TFREMDMSPE EVVASPRASP AKQRGPEAAS NIQQCLFLKK
   361  MGAKGSTPGM FNLPVSLYVT SQGEVLVADR GNYRIQVFTR KGFLKEIRRS PSGIDSFVLS
   421  FLGADLPNLT PLSVAMNCQG LIGVTDSYDN SLKVYTLDGH CVACHRSQLS KPWGITALPS
   481  GQFVVTDVEG GKLWCFTVDR GSGVVKYSCL CSAVRPKFVT CDAEGTVYFT QGLGLNLENR
   541  QNEHHLEGGF SIGSVGPDGQ LGRQISHFFS ENEDFRCIAG MCVDARGDLI VADSSRKEIL
   601  HFPKGGGYSV LIREGLTCPV GIALTPKGQL LVLDCWDHCI KIYSYHLRRY STP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 17 nTPM
  • cerebellum: 13 nTPM
  • fallopian tube: 12 nTPM
  • tongue: 12 nTPM
  • smooth muscle: 10 nTPM
  • cervix: 9.5 nTPM

Single-cell type

  • thymic myoid cells: 35 nCPM
  • decidual stromal cells: 29 nCPM
  • choroid plexus epithelial cells: 27 nCPM
  • early primary spermatocytes: 23 nCPM
  • respiratory ciliated cells: 23 nCPM
  • fallopian tube ciliated cells: 20 nCPM

Immune cell

  • T-reg: 21 nTPM
  • gdT-cell: 11 nTPM
  • naive CD8 T-cell: 9.8 nTPM
  • naive CD4 T-cell: 9.6 nTPM
  • memory CD4 T-cell: 9.5 nTPM
  • memory CD8 T-cell: 8.7 nTPM

Brain region

  • cerebellum: 46 nTPM
  • choroid plexus: 45 nTPM
  • hypothalamus: 25 nTPM
  • cerebral cortex: 23 nTPM
  • hippocampal formation: 22 nTPM
  • basal ganglia: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM32.

Disease | AllUniProt

Conditions TRIM32 is implicated in, by any mechanism.

  • Muscular dystrophy, limb-girdle, autosomal recessive 8 (LGMDR8) MIM:254110
  • Bardet-Biedl syndrome 11 (BBS11) MIM:615988

Disease | GeneticClinVar

70 pathogenic / likely-pathogenic of 761 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM32 as an antibody target. Whether an autoantibody or antibody against TRIM32 could matter depends on whether native TRIM32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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