Seroatlas · Human Serome Atlas

TRIM48

E3 ubiquitin-protein ligase TRIM48

Also known as: RNF101, TRI48_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWZ4
Gene: TRIM48
Ensembl: ENSG00000150244
Chromosome: 11
Canonical length: 224 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q8IWZ4|TRIM48
     1  MSRRIIVGTL QRTQRNMNSG ISQVFQRELT CPICMNYFID PVTIDCGHSF CRPCFYLNWQ
    61  DIPILTQCFE CIKTIQQRNL KTNIRLKKMA SLARKASLWL FLSSEEQMCG IHRETKKMFC
   121  EVDRSLLCLL CSSSQEHRYH RHCPAEWAAE EHWEKLLKKM QSLWEKACEN QRNLNVETTR
   181  ISHWKAFGDI LYRSESVLLH MPQPLNLALR AGPITGLRDR LNQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

skin: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

gastric chief cells: 1.1 nCPM
adrenal cortex cells: 0.9 nCPM
foveolar cells: 0.4 nCPM
melanocytes: 0.4 nCPM
goblet cells: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.99
gnomAD pLI: 0
gnomAD missense Z: -3.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM48 as an antibody target. Whether an autoantibody or antibody against TRIM48 could matter depends on whether native TRIM48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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