Seroatlas · Human Serome Atlas

TRIM45

E3 ubiquitin-protein ligase TRIM45

Also known as: FLJ13181, RNF99, TRI45_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H8W5
Gene
TRIM45
Ensembl
ENSG00000134253
Chromosome
1
Canonical length
580 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Located in cytosol; intercellular bridge; and nucleoplasm. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>Q9H8W5|TRIM45
     1  MSENRKPLLG FVSKLTSGTA LGNSGKTHCP LCLGLFKAPR LLPCLHTVCT TCLEQLEPFS
    61  VVDIRGGDSD TSSEGSIFQE LKPRSLQSQI GILCPVCDAQ VDLPMGGVKA LTIDHLAVND
   121  VMLESLRGEG QGLVCDLCND REVEKRCQTC KANLCHFCCQ AHRRQKKTTY HTMVDLKDLK
   181  GYSRIGKPIL CPVHPAEELR LFCEFCDRPV CQDCVVGEHR EHPCDFTSNV IHKHGDSVWE
   241  LLKGTQPHVE ALEEALAQIH IINSALQKRV EAVAADVRTF SEGYIKAIEE HRDKLLKQLE
   301  DIRAQKENSL QLQKAQLEQL LADMRTGVEF TEHLLTSGSD LEILITKRVV VERLRKLNKV
   361  QYSTRPGVND KIRFCPQEKA GQCRGYEIYG TINTKEVDPA KCVLQGEDLH RAREKQTASF
   421  TLLCKDAAGE IMGRGGDNVQ VAVVPKDKKD SPVRTMVQDN KDGTYYISYT PKEPGVYTVW
   481  VCIKEQHVQG SPFTVMVRRK HRPHSGVFHC CTFCSSGGQK TARCACGGTM PGGYLGCGHG
   541  HKGHPGHPHW SCCGKFNEKS ECTWTGGQSA PRSLLRTVAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 27 nTPM
  • fallopian tube: 13 nTPM
  • heart muscle: 12 nTPM
  • thyroid gland: 11 nTPM
  • pancreas: 11 nTPM
  • prostate: 10 nTPM

Single-cell type

  • myonuclei: 25 nCPM
  • cardiomyocytes: 12 nCPM
  • smooth muscle cells: 11 nCPM
  • adrenal medulla cells: 11 nCPM
  • adrenal cortex cells: 9.3 nCPM
  • respiratory deuterosomal cells: 9.3 nCPM

Immune cell

  • NK-cell: 0.6 nTPM
  • T-reg: 0.5 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • amygdala: 6.5 nTPM
  • cerebral cortex: 6.4 nTPM
  • thalamus: 6.2 nTPM
  • white matter: 6.1 nTPM
  • basal ganglia: 5.9 nTPM
  • medulla oblongata: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM45 as an antibody target. Whether an autoantibody or antibody against TRIM45 could matter depends on whether native TRIM45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM45. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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