Seroatlas · Protein domains

Kelch-type beta-propeller

IPR015915

Definition

This entry represents the 6-bladed Kelch β-propeller, which consists of six 4-stranded β-sheet motifs (or six Kelch repeats). Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified PMID:8453663. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as ring canal kelch protein), creating a 6-bladed β-propeller. The motif is also found in mouse protein MIPP PMID:8453663 and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha-and beta-scruin [[cite:PMID:7593276], [cite:PMID:7822422]], and in galactose oxidase from the fungus Dactylium dendroides [[cite:PMID:8126718], [cite:PMID:2002850]]. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded antiparallel β-sheet motif that forms the repeat unit in a super-barrel structural fold PMID:8182749. The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila PMID:7593276. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase PMID:8126718.

73 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

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