Seroatlas · Human Serome Atlas

RABEPK

Rab9 effector protein with kelch motifs

Also known as: bA65N13.1, RAB9P40, RABEK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6M1
Gene: RABEPK
Ensembl: ENSG00000136933
Chromosome: 9
Canonical length: 372 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in receptor-mediated endocytosis and vesicle docking involved in exocytosis. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q7Z6M1|RABEPK
     1  MKQLPVLEPG DKPRKATWYT LTVPGDSPCA RVGHSCSYLP PVGNAKRGKV FIVGGANPNR
    61  SFSDVHTMDL GKHQWDLDTC KGLLPRYEHA SFIPSCTPDR IWVFGGANQS GNRNCLQVLN
   121  PETRTWTTPE VTSPPPSPRT FHTSSAAIGN QLYVFGGGER GAQPVQDTKL HVFDANTLTW
   181  SQPETLGNPP SPRHGHVMVA AGTKLFIHGG LAGDRFYDDL HCIDISDMKW QKLNPTGAAP
   241  AGCAAHSAVA MGKHVYIFGG MTPAGALDTM YQYHTEEQHW TLLKFDTLLP PGRLDHSMCI
   301  IPWPVTCASE KEDSNSLTLN HEAEKEDSAD KVMSHSGDSH EESQTATLLC LVFGGMNTEG
   361  EIYDDCIVTV VD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABEPK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

liver: 55 nTPM
basal ganglia: 29 nTPM
cerebral cortex: 24 nTPM
midbrain: 23 nTPM
hypothalamus: 21 nTPM
amygdala: 20 nTPM

Single-cell type

hepatocytes: 110 nCPM
late primary spermatocytes: 86 nCPM
early spermatids: 78 nCPM
cytotrophoblasts: 63 nCPM
migrating cytotrophoblasts: 59 nCPM
hepatic stellate cells: 58 nCPM

Immune cell

T-reg: 39 nTPM
naive CD4 T-cell: 38 nTPM
memory CD4 T-cell: 35 nTPM
naive CD8 T-cell: 28 nTPM
neutrophil: 28 nTPM
basophil: 28 nTPM

Brain region

thalamus: 29 nTPM
basal ganglia: 28 nTPM
hypothalamus: 27 nTPM
white matter: 26 nTPM
midbrain: 26 nTPM
pons: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABEPK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PIKFYVE
RAB9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABEPK as an antibody target. Whether an autoantibody or antibody against RABEPK could matter depends on whether native RABEPK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABEPK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABEPK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...