Seroatlas · Human Serome Atlas

KLHDC8B

Kelch domain-containing protein 8B

Also known as: KLD8B_HUMAN, MGC35097

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXV7
Gene
KLHDC8B
Ensembl
ENSG00000185909
Chromosome
3
Canonical length
354 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q8IXV7|KLHDC8B
     1  MSAGGGRAFA WQVFPPMPTC RVYGTVAHQD GHLLVLGGCG RAGLPLDTAE TLDMASHTWL
    61  ALAPLPTARA GAAAVVLGKQ VLVVGGVDEV QSPVAAVEAF LMDEGRWERR ATLPQAAMGV
   121  ATVERDGMVY ALGGMGPDTA PQAQVRVYEP RRDCWLSLPS MPTPCYGAST FLHGNKIYVL
   181  GGRQGKLPVT AFEAFDLEAR TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS
   241  RPHFVNTVEM FDLEHGSWTK LPRSLRMRDK RADFVVGSLG GHIVAIGGLG NQPCPLGSVE
   301  SFSLARRRWE ALPAMPTARC SCSSLQAGPR LFVIGGVAQG PSQAVEALCL RDGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 124 nTPM
  • ovary: 66 nTPM
  • heart muscle: 66 nTPM
  • choroid plexus: 53 nTPM
  • colon: 52 nTPM
  • esophagus: 29 nTPM

Single-cell type

  • platelets: 388 nCPM
  • granulosa cells: 97 nCPM
  • esophageal suprabasal cells: 63 nCPM
  • esophageal apical cells: 61 nCPM
  • syncytiotrophoblasts: 56 nCPM
  • adrenal cortex cells: 53 nCPM

Immune cell

  • eosinophil: 29 nTPM
  • neutrophil: 9.7 nTPM
  • non-classical monocyte: 8.4 nTPM
  • intermediate monocyte: 8 nTPM
  • classical monocyte: 5.4 nTPM
  • total PBMC: 2.4 nTPM

Brain region

  • choroid plexus: 40 nTPM
  • hypothalamus: 32 nTPM
  • pons: 22 nTPM
  • thalamus: 20 nTPM
  • midbrain: 18 nTPM
  • basal ganglia: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLHDC8B.

Disease | AllUniProt

Conditions KLHDC8B is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
1.59
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC8B as an antibody target. Whether an autoantibody or antibody against KLHDC8B could matter depends on whether native KLHDC8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHDC8B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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