Seroatlas · Human Serome Atlas

KLHDC1

Kelch domain-containing protein 1

Also known as: KLDC1_HUMAN, MST025

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7A1
Gene: KLHDC1
Ensembl: ENSG00000197776
Chromosome: 14
Canonical length: 406 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Is active in Cul5-RING ubiquitin ligase complex and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q8N7A1|KLHDC1
     1  MADSQLFCVA EERSGHCAVV DGNFLYVWGG YVSIEDNEVY LPNDEIWTYD IDSGLWRMHL
    61  MEGELPASMS GSCGACINGK LYIFGGYDDK GYSNRLYFVN LRTRDETYIW EKITDFEGQP
   121  PTPRDKLSCW VYKDRLIYFG GYGCRRHSEL QDCFDVHDAS WEEQIFWGWH NDVHIFDTKT
   181  QTWFQPEIKG GVPPQPRAAH TCAVLGNKGY IFGGRVLQTR MNDLHYLNLD TWTWSGRITI
   241  NGESPKHRSW HTLTPIADDK LFLCGGLSAD NIPLSDGWIH NVTTNCWKQL THLPKTRPRL
   301  WHTACLGKEN EIMVFGGSKD DLLALDTGHC NDLLIFQTQP YSLLRSCLDC IGKNSIMLES
   361  QISLLPPKLL QQVLKKITFW AAANHREEQR VQKEETENKY QWISSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 8.9 nTPM

Expression across tissuesHPA

Tissue

ovary: 8.9 nTPM
skeletal muscle: 6.7 nTPM
spinal cord: 6.3 nTPM
cerebellum: 6.1 nTPM
pituitary gland: 5.8 nTPM
endometrium: 5.6 nTPM

Single-cell type

myonuclei: 206 nCPM
retinal ganglion cells: 135 nCPM
adipocytes: 133 nCPM
oligodendrocytes: 113 nCPM
fibro-adipogenic progenitors: 113 nCPM
lactotrophs: 94 nCPM

Immune cell

naive CD4 T-cell: 1.7 nTPM
MAIT T-cell: 1.5 nTPM
naive CD8 T-cell: 1.4 nTPM
plasmacytoid DC: 1.4 nTPM
memory B-cell: 1.2 nTPM
eosinophil: 1 nTPM

Brain region

white matter: 19 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 15 nTPM
cerebellum: 14 nTPM
cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC1 as an antibody target. Whether an autoantibody or antibody against KLHDC1 could matter depends on whether native KLHDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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