Seroatlas · Human Serome Atlas

HCFC2

Host cell factor 2

Also known as: HCF-2, HCFC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5Z7
Gene: HCFC2
Ensembl: ENSG00000111727
Chromosome: 12
Canonical length: 792 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q9Y5Z7|HCFC2
     1  MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF
    61  LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS
   121  GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP
   181  VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT
   241  VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV
   301  SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP
   361  SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG
   421  SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV
   481  DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV
   541  VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD
   601  VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG
   661  IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ
   721  IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR
   781  WLQGNNKKAP LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCFC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

tongue: 11 nTPM
skeletal muscle: 9.5 nTPM
seminal vesicle: 8.9 nTPM
testis: 8.9 nTPM
colon: 8.8 nTPM
blood vessel: 8.4 nTPM

Single-cell type

late primary spermatocytes: 335 nCPM
early spermatids: 236 nCPM
myonuclei: 82 nCPM
adrenal medulla cells: 75 nCPM
early primary spermatocytes: 73 nCPM
late spermatids: 68 nCPM

Immune cell

non-classical monocyte: 1.8 nTPM
intermediate monocyte: 1.1 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.9 nTPM
memory CD8 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.9 nTPM

Brain region

white matter: 17 nTPM
basal ganglia: 14 nTPM
midbrain: 14 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM
cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 3.5
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

antiviral innate immune response
chromatin remodeling
negative regulation of transcription by RNA polymerase II
regulation of DNA-templated transcription
regulation of toll-like receptor 3 signaling pathway
regulation of transcription by RNA polymerase II
viral process
immune response involved in response to exogenous dsRNA

Molecular functions

transcription coactivator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HCFC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCFC2 as an antibody target. Whether an autoantibody or antibody against HCFC2 could matter depends on whether native HCFC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCFC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HCFC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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