KLHDC8A
Kelch domain-containing protein 8A
Also known as: FLJ10748, KLD8A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYD2
- Gene
- KLHDC8A
- Ensembl
- ENSG00000162873
- Chromosome
- 1
- Canonical length
- 350 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Canonical amino-acid sequenceUniProt
350 residues, UniProt reviewed canonical sequence.
>Q8IYD2|KLHDC8A
1 MEVPNVKDFQ WKRLAPLPSR RVYCSLLETG GQVYAIGGCD DNGVPMDCFE VYSPEADQWT
61 ALPRLPTARA GVAVTALGKR IMVIGGVGTN QLPLKVVEMY NIDEGKWKKR SMLREAAMGI
121 SVTAKDYRVY AAGGMGLDLR PHNHLQHYDM LKDMWVSLAP MPTPRYAATS FLRGSKIYVL
181 GGRQSKYAVN AFEVFDIETR SWTKFPNIPY KRAFSSFVTL DNHLYSLGGL RQGRLYRQPK
241 FLRTMDVFDM EQGGWLKMER SFFLKKRRAD FVAGSLSGRV IVAGGLGNQP TVLETAEAFH
301 PGKNKWEILP AMPTPRCACS SIVVKNCLLA VGGVNQGLSD AVEALCVSDSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLHDC8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 278 nTPM
Expression across tissuesHPA
Tissue
- ovary: 278 nTPM
- cerebellum: 28 nTPM
- adrenal gland: 26 nTPM
- retina: 25 nTPM
- hypothalamus: 18 nTPM
- pituitary gland: 17 nTPM
Single-cell type
- ovarian stromal cells: 200 nCPM
- bergmann glia: 118 nCPM
- retinal bipolar cells: 96 nCPM
- granulosa cells: 74 nCPM
- ependymal cells: 69 nCPM
- pituicytes/fscs: 51 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 37 nTPM
- pons: 34 nTPM
- medulla oblongata: 32 nTPM
- cerebellum: 30 nTPM
- cerebral cortex: 29 nTPM
- hippocampal formation: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.9
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLHDC8A as an antibody target. Whether an autoantibody or antibody against KLHDC8A could matter depends on whether native KLHDC8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLHDC8A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KLHDC8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...