Seroatlas · Human Serome Atlas

KLHDC9

Kelch domain-containing protein 9

Also known as: KARCA1, KLDC9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEP7
Gene: KLHDC9
Ensembl: ENSG00000162755
Chromosome: 1
Canonical length: 349 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables cyclin binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q8NEP7|KLHDC9
     1  MAVAVPPGRA AGSGWAWRPV ARDALLARAF HSCTELRGRF YLVGGLLAGG AREPSSDTVV
    61  FDPARGQAVR LGARGSPPRS HHDAAPVDGR WLCVVGGWDG SRRLATVTAL DTERGVWEAW
   121  TGTPGDCPPA GLSSHTCTRI SDRELQVAGR EGGIHTQRRY GSIYTLRLDP SARTYCYKQE
   181  GCHTASRSGH CAALLQTPGP HPGHQLLLFG GCNLAEPEVA GHWSHGKIKE EPPVAPHLME
   241  QLARLVSSGQ GSQKGPHGLR HHSCSVVGPF AVLFGGETLT RARDTICNDL YIYDTRTSPP
   301  LWFHFPCADR GMKRMGHRTC LWNDQLYLVG GFGEDGRTAS PQVCILDFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
cerebral cortex: 6.3 nTPM
basal ganglia: 5.2 nTPM
kidney: 4.8 nTPM
pituitary gland: 4 nTPM
hypothalamus: 3.9 nTPM

Single-cell type

late spermatids: 590 nCPM
late primary spermatocytes: 473 nCPM
early spermatids: 382 nCPM
early primary spermatocytes: 99 nCPM
respiratory ciliated cells: 89 nCPM
epididymal efferent duct ciliated cells: 87 nCPM

Immune cell

memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 5.6 nTPM
choroid plexus: 5.4 nTPM
midbrain: 4.7 nTPM
cerebral cortex: 4.4 nTPM
pons: 4.3 nTPM
basal ganglia: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

cyclin binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHDC9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CCNA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC9 as an antibody target. Whether an autoantibody or antibody against KLHDC9 could matter depends on whether native KLHDC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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