Seroatlas · Human Serome Atlas

KLHDC4

Kelch domain-containing protein 4

Also known as: DKFZp434G0522, KLDC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBB5
Gene: KLHDC4
Ensembl: ENSG00000104731
Chromosome: 16
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Kinetochore

OverviewNCBI Gene

No narrative summary is available for KLHDC4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8TBB5|KLHDC4
     1  MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR TQTVELPCPP
    61  PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY NTRKDTWTKV DIPSPPPRRC
   121  AHQAVVVPQG GGQLWVFGGE FASPNGEQFY HYKDLWVLHL ATKTWEQVKS TGGPSGRSGH
   181  RMVAWKRQLI LFGGFHESTR DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP
   241  QGGIVVYGGY SKQRVKKDVD KGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS
   301  VAMAPNHQTL FFGGVCDEEE EESLSGEFFN DLYFYDATRN RWFEGQLKGP KSEKKKRRRG
   361  RKEEPEGGSR PACGGAGTQG PVQLVKEVVA EDGTVVTIKQ VLTAPGSAGQ PRSEDEDSLE
   421  EAGSPAPGPC PRSNAMLAVK HGVLYVYGGM FEAGDRQVTL SDLHCLDLHR MEAWKALVEM
   481  DPETQEWLEE TDSEEDSEEV EGAEGGVDDE DSGEESGAED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

spleen: 18 nTPM
pancreas: 17 nTPM
cerebellum: 16 nTPM
lymph node: 15 nTPM
thymus: 15 nTPM
liver: 13 nTPM

Single-cell type

late spermatids: 130 nCPM
pdcs: 113 nCPM
nk-cells: 100 nCPM
early spermatids: 79 nCPM
somatotrophs: 68 nCPM
plasma cells: 64 nCPM

Immune cell

NK-cell: 26 nTPM
gdT-cell: 18 nTPM
MAIT T-cell: 16 nTPM
non-classical monocyte: 16 nTPM
memory CD8 T-cell: 14 nTPM
naive CD8 T-cell: 11 nTPM

Brain region

cerebellum: 26 nTPM
hippocampal formation: 18 nTPM
hypothalamus: 18 nTPM
medulla oblongata: 17 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -2.62
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHDC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC4 as an antibody target. Whether an autoantibody or antibody against KLHDC4 could matter depends on whether native KLHDC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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