Seroatlas · Human Serome Atlas

KLHDC7B

Kelch domain-containing protein 7B

Also known as: KLD7B_HUMAN, MGC16635

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G42
Gene: KLHDC7B
Ensembl: ENSG00000130487
Chromosome: 22
Canonical length: 594 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

No narrative summary is available for KLHDC7B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q96G42|KLHDC7B
     1  MVLRSHPFPR QDRPQGSVPR AVPGSPVGPS TSTHSEDRHG PSSSVGTVIG TGTGGLVEAG
    61  GQPQPRSSET NGSPSPDPPP GLRGEGTREK SLDPLPQAAM PRGPAQPPAQ RPPGPAASSS
   121  ARRSQPVPQL RKRSRCEIAP SSEQEVRPAA SGDPQGEAPG EGGSPAGRSG ALTEKQEEAR
   181  KLMVFLQRPG GWGVVEGPRK PSSRALEPAT AAALRRRLDL GSCLDVLAFA QQHGEPGLAQ
   241  ETYALMSDNL LRVLGDPCLY RRLSAADRER ILSLRTGRGR AVLGVLVLPS LYQGGRSGLP
   301  RGPRGEEPPA AAPVSLPLPA HLHVFNPREN TWRPLTQVPE EAPLRGCGLC TMHNYLFLAG
   361  GIRGSGAKAV CSNEVFCYNP LTNIWSQVRP MQQARAQLKL VALDGLLYAI GGECLYSMEC
   421  YDPRTDAWTP RAPLPAGTFP VAHEAVACRG DIYVTGGHLF YRLLRYSPVK DAWDECPYSA
   481  SHRRSSDIVA LGGFLYRFDL LRGVGAAVMR YNTVTGSWSR AASLPLPAPA PLHCTTLGNT
   541  IYCLNPQVTA TFTVSGGTAQ FQAKELQPFP LGSTGVLSPF ILTLPPEDRL QTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
thymus: 4.8 nTPM
kidney: 3.4 nTPM
spleen: 2.5 nTPM
lymph node: 2.1 nTPM
appendix: 1.9 nTPM

Single-cell type

endometrial secretory cells: 8.1 nCPM
conjunctival goblet cells: 7.8 nCPM
mast cells: 7.8 nCPM
renal connecting tubule cells: 6 nCPM
kupffer cells: 5.1 nCPM
breast hormone-responsive cells: 5 nCPM

Immune cell

memory CD8 T-cell: 2.6 nTPM
naive CD4 T-cell: 2.3 nTPM
memory CD4 T-cell: 2.1 nTPM
gdT-cell: 2 nTPM
naive CD8 T-cell: 2 nTPM
T-reg: 2 nTPM

Brain region

medulla oblongata: 0.9 nTPM
thalamus: 0.7 nTPM
pons: 0.4 nTPM
spinal cord: 0.4 nTPM
cerebral cortex: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 1.19
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC7B as an antibody target. Whether an autoantibody or antibody against KLHDC7B could matter depends on whether native KLHDC7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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