Seroatlas · Human Serome Atlas

KLHDC2

Kelch domain-containing protein 2

Also known as: HCLP-1, KLDC2_HUMAN, LCP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2U9
Gene: KLHDC2
Ensembl: ENSG00000165516
Chromosome: 14
Canonical length: 406 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Nuclear bodies

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nuclear body and nuclear membrane. Is active in Cul2-RING ubiquitin ligase complex and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9Y2U9|KLHDC2
     1  MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD
    61  FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM
   121  LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET
   181  SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA
   241  RMNDLHYLNL DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY
   301  CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH SNEILIFSVQ
   361  PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS NNTSGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 50 nTPM
liver: 46 nTPM
tongue: 36 nTPM
heart muscle: 36 nTPM
kidney: 32 nTPM
pancreas: 29 nTPM

Single-cell type

late primary spermatocytes: 293 nCPM
parietal cells: 202 nCPM
early primary spermatocytes: 190 nCPM
enterocytes: 143 nCPM
esophageal apical cells: 128 nCPM
cytotrophoblasts: 128 nCPM

Immune cell

naive CD4 T-cell: 24 nTPM
eosinophil: 20 nTPM
naive B-cell: 19 nTPM
memory B-cell: 18 nTPM
T-reg: 18 nTPM
memory CD8 T-cell: 17 nTPM

Brain region

choroid plexus: 29 nTPM
white matter: 28 nTPM
cerebral cortex: 28 nTPM
hypothalamus: 27 nTPM
pons: 26 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.03
gnomAD missense Z: 0.93
DepMap mean gene effect: 0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC2 as an antibody target. Whether an autoantibody or antibody against KLHDC2 could matter depends on whether native KLHDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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