Seroatlas · Human Serome Atlas

KLHDC3

Kelch domain-containing protein 3

Also known as: dJ20C7.3, hPeas, KLDC3_HUMAN, PEAS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ90
Gene: KLHDC3
Ensembl: ENSG00000124702
Chromosome: 6
Canonical length: 382 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q9BQ90|KLHDC3
     1  MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP
    61  PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG ACNVLYAFDV NTHKWFTPRV
   121  SGTVPGARDG HSACVLGKIM YIFGGYEQQA DCFSNDIHKL DTSTMTWTLI CTKGSPARWR
   181  DFHSATMLGS HMYVFGGRAD RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR
   241  SHSAFGYNGE LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG
   301  DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN LDQSCLPHDI
   361  RWELNAMTTN SNISRPIVSS HG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 371 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 371 nTPM
cerebral cortex: 225 nTPM
tongue: 190 nTPM
testis: 187 nTPM
amygdala: 141 nTPM
cerebellum: 140 nTPM

Single-cell type

late spermatids: 2,542 nCPM
late primary spermatocytes: 570 nCPM
early spermatids: 557 nCPM
megakaryocytes: 204 nCPM
extravillous trophoblasts: 140 nCPM
migrating cytotrophoblasts: 134 nCPM

Immune cell

eosinophil: 100 nTPM
myeloid DC: 90 nTPM
classical monocyte: 83 nTPM
intermediate monocyte: 79 nTPM
total PBMC: 75 nTPM
naive CD4 T-cell: 65 nTPM

Brain region

cerebral cortex: 182 nTPM
basal ganglia: 161 nTPM
thalamus: 147 nTPM
hippocampal formation: 140 nTPM
pons: 139 nTPM
midbrain: 137 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 3.45
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHDC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC3 as an antibody target. Whether an autoantibody or antibody against KLHDC3 could matter depends on whether native KLHDC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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