Seroatlas · Human Serome Atlas

MKLN1

Muskelin

Also known as: MKLN1_HUMAN, TWA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UL63
Gene
MKLN1
Ensembl
ENSG00000128585
Chromosome
7
Canonical length
735 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

735 residues, UniProt reviewed canonical sequence.

>Q9UL63|MKLN1
     1  MAAGGAVAAA PECRLLPYAL HKWSSFSSTY LPENILVDKP NDQSSRWSSE SNYPPQYLIL
    61  KLERPAIVQN ITFGKYEKTH VCNLKKFKVF GGMNEENMTE LLSSGLKNDY NKETFTLKHK
   121  IDEQMFPCRF IKIVPLLSWG PSFNFSIWYV ELSGIDDPDI VQPCLNWYSK YREQEAIRLC
   181  LKHFRQHNYT EAFESLQKKT KIALEHPMLT DIHDKLVLKG DFDACEELIE KAVNDGLFNQ
   241  YISQQEYKPR WSQIIPKSTK GDGEDNRPGM RGGHQMVIDV QTETVYLFGG WDGTQDLADF
   301  WAYSVKENQW TCISRDTEKE NGPSARSCHK MCIDIQRRQI YTLGRYLDSS VRNSKSLKSD
   361  FYRYDIDTNT WMLLSEDTAA DGGPKLVFDH QMCMDSEKHM IYTFGGRILT CNGSVDDSRA
   421  SEPQFSGLFA FNCQCQTWKL LREDSCNAGP EDIQSRIGHC MLFHSKNRCL YVFGGQRSKT
   481  YLNDFFSYDV DSDHVDIISD GTKKDSGMVP MTGFTQRATI DPELNEIHVL SGLSKDKEKR
   541  EENVRNSFWI YDIVRNSWSC VYKNDQAAKD NPTKSLQEEE PCPRFAHQLV YDELHKVHYL
   601  FGGNPGKSCS PKMRLDDFWS LKLCRPSKDY LLRHCKYLIR KHRFEEKAQV DPLSALKYLQ
   661  NDLYITVDHS DPEETKEFQL LASALFKSGS DFTALGFSDV DHTYAQRTQL FDTLVNFFPD
   721  SMTPPKGNLV DLITL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MKLN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • retina: 20 nTPM
  • prostate: 15 nTPM
  • liver: 14 nTPM
  • cerebral cortex: 13 nTPM
  • kidney: 13 nTPM
  • breast: 13 nTPM

Single-cell type

  • choroid plexus epithelial cells: 1,022 nCPM
  • neutrophils: 1,019 nCPM
  • astrocytes: 895 nCPM
  • myonuclei: 842 nCPM
  • bergmann glia: 841 nCPM
  • pituicytes/fscs: 820 nCPM

Immune cell

  • neutrophil: 9.5 nTPM
  • naive CD4 T-cell: 1.7 nTPM
  • naive B-cell: 1.6 nTPM
  • eosinophil: 1.4 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • non-classical monocyte: 1.3 nTPM

Brain region

  • midbrain: 75 nTPM
  • medulla oblongata: 72 nTPM
  • cerebellum: 72 nTPM
  • hypothalamus: 71 nTPM
  • thalamus: 70 nTPM
  • basal ganglia: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.74
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MKLN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MKLN1 as an antibody target. Whether an autoantibody or antibody against MKLN1 could matter depends on whether native MKLN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MKLN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MKLN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MKLN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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