Seroatlas · Human Serome Atlas

KLHDC7A

Kelch domain-containing protein 7A

Also known as: FLJ38753, KLD7A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VTJ3
Gene: KLHDC7A
Ensembl: ENSG00000179023
Chromosome: 1
Canonical length: 777 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q5VTJ3|KLHDC7A
     1  MFPRGAEAQD WHLDMQLTGK VVLSAAALLL VTVAYRLYKS RPAPAQRWGG NGQAEAKEEA
    61  EGSGQPAVQE ASPGVLLRGP RRRRSSKRAE APQGCSCENP RGPYVLVTGA TSTDRKPQRK
   121  GSGEERGGQG SDSEQVPPCC PSQETRTAVG SNPDPPHFPR LGSEPKSSPA GLIAAADGSC
   181  AGGEPSPWQD SKPREHPGLG QLEPPHCHYV APLQGSSDMN QSWVFTRVIG VSREEAGALE
   241  AASDVDLTLH QQEGAPNSSY TFSSIARVRM EEHFIQKAEG VEPRLKGKVY DYYVESTSQA
   301  IFQGRLAPRT AALTEVPSPR PPPGSLGTGA ASGGQAGDTK GAAERAASPQ TGPWPSTRGF
   361  SRKESLLQIA ENPELQLQPD GFRLPAPPCP DPGALPGLGR SSREPHVQPV AGTNFFHIPL
   421  TPASAPQVRL DLGNCYEVLT LAKRQNLEAL KEAAYKVMSE NYLQVLRSPD IYGCLSGAER
   481  ELILQRRLRG RQYLVVADVC PKEDSGGLCC YDDEQDVWRP LARMPPEAVS RGCAICSLFN
   541  YLFVVSGCQG PGHQPSSRVF CYNPLTGIWS EVCPLNQARP HCRLVALDGH LYAIGGECLN
   601  SVERYDPRLD RWDFAPPLPS DTFALAHTAT VRAKEIFVTG GSLRFLLFRF SAQEQRWWAG
   661  PTGGSKDRTA EMVAVNGFLY RFDLNRSLGI AVYRCSASTR LWYECATYRT PYPDAFQCAV
   721  VDNLIYCVGR RSTLCFLADS VSPRFVPKEL RSFPAPQGTL LPTVLTLPTP DLPQTRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

kidney: 18 nTPM
choroid plexus: 6.1 nTPM
liver: 4.6 nTPM
stomach: 4.6 nTPM
breast: 4.3 nTPM
pancreas: 3 nTPM

Single-cell type

foveolar cells: 16 nCPM
choroid plexus epithelial cells: 11 nCPM
respiratory ciliated cells: 9.7 nCPM
hepatocytes: 8.5 nCPM
salivary duct cells: 8.5 nCPM
conjunctival goblet cells: 7.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 19 nTPM
cerebellum: 1.5 nTPM
hippocampal formation: 1.3 nTPM
cerebral cortex: 0.4 nTPM
thalamus: 0.3 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC7A as an antibody target. Whether an autoantibody or antibody against KLHDC7A could matter depends on whether native KLHDC7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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