Seroatlas · Human Serome Atlas

KLHDC10

Kelch domain-containing protein 10

Also known as: KIAA0265, KLD10_HUMAN, slim

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PID8
Gene
KLHDC10
Ensembl
ENSG00000128607
Chromosome
7
Canonical length
442 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in rescue of stalled ribosome and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q6PID8|KLHDC10
     1  MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG RPHLPGKKKI
    61  RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD NTNLYVFGGY NPDYDESGGP
   121  DNEDYPLFRE LWRYHFATGV WHQMGTDGYM PRELASMSLV LHGNNLLVFG GTGIPFGESN
   181  GNDVHVCNVK YKRWALLSCR GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN
   241  TREWTQLKPN NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE
   301  EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT FQWVKLPATM
   361  PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL VVPSLLELAW EKLLAAFPNL
   421  ANLSRTQLLH LGLTQGLIER LK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHDC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • testis: 36 nTPM
  • parathyroid gland: 29 nTPM
  • skeletal muscle: 23 nTPM
  • liver: 22 nTPM
  • cerebellum: 21 nTPM
  • tongue: 21 nTPM

Single-cell type

  • choroid plexus epithelial cells: 232 nCPM
  • adrenal cortex cells: 179 nCPM
  • adipocytes: 163 nCPM
  • corticotrophs: 162 nCPM
  • lactotrophs: 160 nCPM
  • distal convoluted tubule cells: 157 nCPM

Immune cell

  • naive B-cell: 1.1 nTPM
  • T-reg: 0.9 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • gdT-cell: 0.6 nTPM
  • intermediate monocyte: 0.6 nTPM

Brain region

  • hypothalamus: 66 nTPM
  • cerebellum: 58 nTPM
  • midbrain: 55 nTPM
  • pons: 48 nTPM
  • choroid plexus: 48 nTPM
  • basal ganglia: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.93
gnomAD missense Z
3.41
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHDC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHDC10 as an antibody target. Whether an autoantibody or antibody against KLHDC10 could matter depends on whether native KLHDC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHDC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHDC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHDC10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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