Seroatlas · Human Serome Atlas

FBXO42

F-box only protein 42

Also known as: Fbx42, FBX42_HUMAN, KIAA1332

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P3S6
Gene: FBXO42
Ensembl: ENSG00000037637
Chromosome: 1
Canonical length: 717 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

Canonical amino-acid sequenceUniProt

717 residues, UniProt reviewed canonical sequence.

>Q6P3S6|FBXO42
     1  MASSSDSEDD SFMAVDQEET VLEGTMDQDE EPHPVLEAEE TRHNRSMSEL PEEVLEYILS
    61  FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG NIQWESRTYP YPGTPITQRF
   121  SHSACYYDAN QSMYVFGGCT QSSCNAAFND LWRLDLNSKE WIRPLASGSY PSPKAGATLV
   181  VYKDLLVLFG GWTRPSPYPL HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI
   241  DDKMIVFGGS LGSRQMSNDV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDATILILG
   301  GCGGPNALFK DAWLLHMHSG PWAWQPLKVE NEEHGAPELW CHPACRVGQC VVVFSQAPSG
   361  RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE APCVNGRWGT LRPRAQRQTP
   421  SGSREGSLSP ARGDGSPILN GGSLSPGTAA VGGSSLDSPV QAISPSTPSA PEGYDLKIGL
   481  SLAPRRGSLP DQKDLRLGSI DLNWDLKPAS SSNPMDGMDN RTVGGSMRHP PEQTNGVHTP
   541  PHVASALAGA VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPGSPGS QSLSSGETVP
   601  IPRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD IKDTKEKGRV
   661  KWKVFNSSSV VGPPETSLHT VVQGRGELII FGGLMDKKQN VKYYPKTNAL YFVRAKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 35 nTPM
skin: 27 nTPM
skeletal muscle: 21 nTPM
tongue: 21 nTPM
urinary bladder: 20 nTPM
endometrium: 19 nTPM

Single-cell type

myonuclei: 259 nCPM
cardiomyocytes: 158 nCPM
adipocytes: 157 nCPM
neutrophils: 156 nCPM
retinal horizontal cells: 150 nCPM
neutrophil progenitors: 149 nCPM

Immune cell

eosinophil: 19 nTPM
intermediate monocyte: 16 nTPM
naive B-cell: 14 nTPM
myeloid DC: 14 nTPM
non-classical monocyte: 13 nTPM
NK-cell: 12 nTPM

Brain region

cerebellum: 33 nTPM
pons: 28 nTPM
cerebral cortex: 28 nTPM
hypothalamus: 28 nTPM
basal ganglia: 27 nTPM
medulla oblongata: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 2.09
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

F-box domain
Kelch-type beta-propeller
F-box-like domain superfamily
F-box-like
F-box only substrate-recognition component
FBX42, beta-propeller domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO42 as an antibody target. Whether an autoantibody or antibody against FBXO42 could matter depends on whether native FBXO42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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