SCAN domain
IPR003309
Definition
A number of C2H2-zinc finger proteins contain a highly conserved N-terminal motif termed the SCAN (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) domain. The SCAN domain has been shown to be able to mediate homo- and hetero-oligomerisation PMID:10567577. These proteins can either activate or repress transcription, although isolated recombinant SCAN domains do not modulate significantly the transcription [[cite:PMID:8065901], [cite:PMID:7673192]]. In addition to these zinc finger transcription factors, an isolated SCAN domain without adjacent zinc finger motifs has been identified in some proteins [[cite:PMID:10393183], [cite:PMID:10747874]]. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein PMID:15629724. The SCAN domain is enriched in hydrophobic and negatively charged residues with a L-X(6)-L motif at its core. This core is flanked by A, E, L, M, H and C residues that are frequently found in α-helices PMID:7673192. Predictions of the secondary structure of the domain suggest the presence of at least three α-helices that are separated from one another by short looped regions bounded by proline residues PMID:10567577. It has been shown to be a selective oligomerization domain that mediates homotypic and heterotypic interactions between SCAN box containing proteins [[cite:PMID:10747874], [cite:PMID:10567577]].
60 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (60 proteins: gene, accession, name)
- MZF1
- PEG3
- PGBD1
- SCAND1
- SCAND2P
- SCAND3
- ZFP69B
- ZKSCAN1
- ZKSCAN2
- ZKSCAN3
- ZKSCAN4
- ZKSCAN5
- ZKSCAN7
- ZKSCAN8
- ZNF165
- ZNF174
- ZNF18
- ZNF197
- ZNF202
- ZNF213
- ZNF215
- ZNF232
- ZNF24
- ZNF263
- ZNF274
- ZNF287
- ZNF394
- ZNF396
- ZNF397
- ZNF444
- ZNF445
- ZNF446
- ZNF449
- ZNF483
- ZNF496
- ZNF500
- ZNF75CP
- ZNF75D
- ZSCAN1
- ZSCAN10
- ZSCAN12
- ZSCAN16
- ZSCAN18
- ZSCAN2
- ZSCAN20
- ZSCAN21
- ZSCAN22
- ZSCAN23
- ZSCAN25
- ZSCAN26
- ZSCAN29
- ZSCAN30
- ZSCAN31
- ZSCAN32
- ZSCAN4
- ZSCAN5A
- ZSCAN5B
- ZSCAN5C
- ZSCAN5DP
- ZSCAN9
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