Seroatlas · Human Serome Atlas

ZSCAN23

Zinc finger and SCAN domain-containing protein 23

Also known as: dJ29K1.3.1, ZNF390, ZNF453, ZSC23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MJ62
Gene: ZSCAN23
Ensembl: ENSG00000187987
Chromosome: 6
Canonical length: 389 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q3MJ62|ZSCAN23
     1  MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR FRQFCYQESP
    61  GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL PEELQAWVRQ HRPVSGEEAV
   121  TVLEDLEREL DDPGEQVLSH AHEQEEFVKE KATPGAAQES SNDQFQTLEE QLGYNLREVC
   181  PVQEIDGKAG TWNVELAPKR EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR
   241  VSSSVERPYI CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT
   301  GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK HQRIHTGERP
   361  YECEECGKNF IYHCNLIQHR KVHPVAESS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

retina: 1.2 nTPM
epididymis: 1.1 nTPM
ovary: 0.8 nTPM
thyroid gland: 0.8 nTPM
breast: 0.7 nTPM
endometrium: 0.7 nTPM

Single-cell type

choroid plexus epithelial cells: 32 nCPM
bergmann glia: 25 nCPM
oligodendrocyte progenitor cells: 25 nCPM
pituitary stem cells: 23 nCPM
adrenal medulla cells: 21 nCPM
rod photoreceptor cells: 20 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.5 nTPM
cerebral cortex: 2.4 nTPM
basal ganglia: 2.2 nTPM
hypothalamus: 2.1 nTPM
medulla oblongata: 2.1 nTPM
midbrain: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 1.48
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN23 as an antibody target. Whether an autoantibody or antibody against ZSCAN23 could matter depends on whether native ZSCAN23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...