ZSCAN1

Protein identityUniProt · HPA

UniProt accession

Q8NBB4

Gene

ZSCAN1

Ensembl

ENSG00000152467

Chromosome

19

Canonical length

408 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q8NBB4|ZSCAN1
     1  MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS GPHLALGQLW
    61  TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS QGPRSCREAA SLVEDLTQMC
   121  QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ KEPSQASELI LDAVAAAPAL PEESEWLETT
   181  QLQQSLHTRA EAEAPRAPGL LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG
   241  PSAQRISPRR RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV
   301  FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK APRSKGPRES
   361  VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK LHTAHGHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

16 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for ZSCAN1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.59

gnomAD pLI

0

gnomAD missense Z

0.01

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• SCAN domain
• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• SCAN domain superfamily
• SCAN domain and C2H2-type zinc finger
• Zinc finger, C2H2 type
• SCAN domain

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger