ZNF263
Zinc finger protein 263
Also known as: FPM315, ZKSCAN12, ZN263_HUMAN, ZSCAN44
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O14978
- Gene
- ZNF263
- Ensembl
- ENSG00000006194
- Chromosome
- 16
- Canonical length
- 683 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Mitotic spindle,Cytosol
OverviewNCBI Gene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
683 residues, UniProt reviewed canonical sequence.
>O14978|ZNF263
1 MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ EAAGPREALS
61 RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR VQELHPESGE EAVTLVEDMQ
121 RELGRLRQQV TNHGRGTEVL LEEPLPLETA RESPSFKLEP METERSPGPR LQELLGPSPQ
181 RDPQAVKERA LSAPWLSLFP PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA
241 LSRDTVQESY ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF
301 ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE GGMEQALAGA
361 SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH AAERLCMGVD CTEIFGGNPR
421 FLSLHRAHLG EEAHKCLECG KCFSQNTHLT RHQRTHTGEK PYQCNICGKC FSCNSNLHRH
481 QRTHTGEKPY KCPECGEIFA HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH
541 ERERLYPFSE CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE
601 KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL RTHTGERPYK
661 CSECGESFSR SSRLMSHQRT HTGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF263 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- ovary: 24 nTPM
- choroid plexus: 21 nTPM
- pituitary gland: 21 nTPM
- cerebellum: 20 nTPM
- spleen: 20 nTPM
- fallopian tube: 20 nTPM
Single-cell type
- late primary spermatocytes: 64 nCPM
- early spermatids: 52 nCPM
- late spermatids: 44 nCPM
- adrenal medulla cells: 32 nCPM
- cardiomyocytes: 32 nCPM
- microglia: 31 nCPM
Immune cell
- eosinophil: 3.7 nTPM
- naive CD4 T-cell: 3 nTPM
- memory CD8 T-cell: 2.9 nTPM
- naive B-cell: 2.9 nTPM
- NK-cell: 2.6 nTPM
- memory CD4 T-cell: 2.4 nTPM
Brain region
- cerebral cortex: 26 nTPM
- white matter: 22 nTPM
- cerebellum: 22 nTPM
- choroid plexus: 21 nTPM
- medulla oblongata: 20 nTPM
- hippocampal formation: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.97
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF263 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF263 as an antibody target. Whether an autoantibody or antibody against ZNF263 could matter depends on whether native ZNF263 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF263 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF263 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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