Seroatlas · Human Serome Atlas

ZNF232

Zinc finger protein 232

Also known as: ZN232_HUMAN, ZSCAN11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNY5
Gene
ZNF232
Ensembl
ENSG00000167840
Chromosome
17
Canonical length
444 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>Q9UNY5|ZNF232
     1  MEPPGPVRGP LQDSSWYEPS AELVQTRMAV SLTAAETLAL QGTQGQEKMM MMGPKEEEQS
    61  CEYETRLPGN HSTSQEIFRQ RFRHLRYQET PGPREALSQL RVLCCEWLRP EKHTKEQILE
   121  FLVLEQFLTI LPEELQSWVR GHHPKSGEEA VTVLEDLEKG LEPEPQVPGP AHGPAQEEPW
   181  EKKESLGAAQ EALSIQLQPK ETQPFPKSEQ VYLHFLSVVT EDGPEPKDKG SLPQPPITEV
   241  ESQVFSEKLA TDTSTFEATS EGTLELQQRN PKAERLRWSP AQEESFRQMV VIHKEIPTGK
   301  KDHECSECGK TFIYNSHLVV HQRVHSGEKP YKCSDCGKTF KQSSNLGQHQ RIHTGEKPFE
   361  CNECGKAFRW GAHLVQHQRI HSGEKPYECN ECGKAFSQSS YLSQHRRIHS GEKPFICKEC
   421  GKAYGWCSEL IRHRRVHARK EPSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF232 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
9 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 9 nTPM
  • ovary: 7.4 nTPM
  • fallopian tube: 5.7 nTPM
  • retina: 5.5 nTPM
  • smooth muscle: 5.4 nTPM
  • tonsil: 5.4 nTPM

Single-cell type

  • early primary spermatocytes: 39 nCPM
  • respiratory ciliated cells: 29 nCPM
  • cardiomyocytes: 29 nCPM
  • differentiating spermatogonia: 22 nCPM
  • oocytes: 18 nCPM
  • fallopian tube ciliated cells: 18 nCPM

Immune cell

  • memory B-cell: 6 nTPM
  • intermediate monocyte: 5.5 nTPM
  • naive B-cell: 5.4 nTPM
  • MAIT T-cell: 4.8 nTPM
  • myeloid DC: 4.1 nTPM
  • naive CD4 T-cell: 3.7 nTPM

Brain region

  • choroid plexus: 8.3 nTPM
  • cerebellum: 7.1 nTPM
  • white matter: 6.9 nTPM
  • hypothalamus: 5.6 nTPM
  • thalamus: 5.6 nTPM
  • cerebral cortex: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.27
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF232 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF232 as an antibody target. Whether an autoantibody or antibody against ZNF232 could matter depends on whether native ZNF232 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF232 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF232 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF232. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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