Seroatlas · Human Serome Atlas

ZNF18

Zinc finger protein 18

Also known as: HDSG1, KOX11, Zfp535, ZKSCAN6, ZNF18_HUMAN, ZNF535, ZSCAN38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17022
Gene: ZNF18
Ensembl: ENSG00000154957
Chromosome: 17
Canonical length: 549 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>P17022|ZNF18
     1  MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ VMSGPHETLK
    61  QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW VRKQCPGSGE EAVTLVESLK
   121  GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ VGEVEPHLEV VPQELGLENS SSGPGELLSH
   181  IVKEESDTEA ELALAASQPA RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM
   241  LETYGKMVSG AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL
   301  ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI QDEGTGEQLS
   361  PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR APMAQKLPTC RECGKTFYRN
   421  SQLIFHQRTH TGETYFQCTI CKKAFLRSSD FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR
   481  HHEKIHTGEK PYKCPICEKS FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR
   541  SHLGKKPFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
bone marrow: 13 nTPM
liver: 12 nTPM
spleen: 10 nTPM
skin: 9.2 nTPM
lymph node: 8.2 nTPM

Single-cell type

late spermatids: 42 nCPM
early spermatids: 40 nCPM
neutrophils: 29 nCPM
late primary spermatocytes: 15 nCPM
astrocytes: 14 nCPM
adipocytes: 14 nCPM

Immune cell

neutrophil: 19 nTPM
T-reg: 11 nTPM
basophil: 11 nTPM
gdT-cell: 10 nTPM
naive CD8 T-cell: 10 nTPM
naive CD4 T-cell: 10 nTPM

Brain region

white matter: 15 nTPM
pons: 14 nTPM
basal ganglia: 13 nTPM
medulla oblongata: 13 nTPM
hypothalamus: 13 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF18 as an antibody target. Whether an autoantibody or antibody against ZNF18 could matter depends on whether native ZNF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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