Seroatlas · Human Serome Atlas

ZNF165

Zinc finger protein 165

Also known as: CT53, ZN165_HUMAN, ZSCAN7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49910
Gene: ZNF165
Ensembl: ENSG00000197279
Chromosome: 6
Canonical length: 485 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Microtubules

OverviewNCBI Gene

This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>P49910|ZNF165
     1  MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ LFRQFCYQDS
    61  PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI LPGDLQAWVH EHYPESGEEA
   121  VTILEDLERG TDEAVLQVQA HEHGQEIFQK KVSPPGPALN VKLQPVETKA HFDSSEPQLL
   181  WDCDNESENS RSMPKLEIFE KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE
   241  SGESQRLSSA QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS
   301  FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG KAFRHSSKLA
   361  RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF GCKECGRAFN LNSHLIRHQR
   421  IHTREKPYEC SECGKTFRVS SHLIRHFRIH TGEKPYECSE CGRAFSQSSN LSQHQRIHMR
   481  ENLLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF165 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
epididymis: 6.4 nTPM
parathyroid gland: 6 nTPM
choroid plexus: 4.7 nTPM
pancreas: 4.4 nTPM
rectum: 4.2 nTPM

Single-cell type

epididymal principal cells: 662 nCPM
epididymal efferent duct ciliated cells: 340 nCPM
epididymal basal cells: 310 nCPM
epididymal clear cells: 263 nCPM
colonocytes: 152 nCPM
late primary spermatocytes: 149 nCPM

Immune cell

naive B-cell: 11 nTPM
memory B-cell: 9.1 nTPM
basophil: 7.7 nTPM
plasmacytoid DC: 7.2 nTPM
eosinophil: 4.4 nTPM
naive CD4 T-cell: 3.2 nTPM

Brain region

choroid plexus: 7 nTPM
pons: 4 nTPM
cerebral cortex: 3.6 nTPM
medulla oblongata: 3.4 nTPM
white matter: 3.4 nTPM
midbrain: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.73
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF165 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF165 as an antibody target. Whether an autoantibody or antibody against ZNF165 could matter depends on whether native ZNF165 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF165 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF165 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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