Seroatlas · Human Serome Atlas

ZNF444

Zinc finger protein 444

Also known as: EZF2, FLJ11137, ZN444_HUMAN, ZSCAN17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0Y2
Gene: ZNF444
Ensembl: ENSG00000167685
Chromosome: 19
Canonical length: 327 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q8N0Y2|ZNF444
     1  MEVAVPVKQE AEGLALDSPW HRFRRFHLGD APGPREALGL LRALCRDWLR PEVHTKEQML
    61  ELLVLEQFLS ALPADTQAWV CSRQPQSGEE AVALLEELWG PAASPDGSSA TRVPQDVTQG
   121  PGATGGKEDS GMIPLAGTAP GAEGPAPGDS QAVRPYKQEP SSPPLAPGLP AFLAAPGTTS
   181  CPECGKTSLK PAHLLRHRQS HSGEKPHACP ECGKAFRRKE HLRRHRDTHP GSPGSPGPAL
   241  RPLPAREKPH ACCECGKTFY WREHLVRHRK THSGARPFAC WECGKGFGRR EHVLRHQRIH
   301  GRAAASAQGA VAPGPDGGGP FPPWPLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF444 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

liver: 64 nTPM
pancreas: 45 nTPM
cerebral cortex: 40 nTPM
basal ganglia: 36 nTPM
cerebellum: 35 nTPM
amygdala: 35 nTPM

Single-cell type

late spermatids: 62 nCPM
respiratory ciliated cells: 52 nCPM
hepatocytes: 50 nCPM
tuft cells: 46 nCPM
pituitary stem cells: 45 nCPM
alveolar cells type 2: 45 nCPM

Immune cell

memory CD4 T-cell: 4 nTPM
memory CD8 T-cell: 4 nTPM
naive CD4 T-cell: 4 nTPM
T-reg: 2.9 nTPM
naive CD8 T-cell: 2.7 nTPM
MAIT T-cell: 2.5 nTPM

Brain region

medulla oblongata: 62 nTPM
amygdala: 52 nTPM
midbrain: 50 nTPM
thalamus: 50 nTPM
cerebral cortex: 50 nTPM
white matter: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.87
gnomAD missense Z: 1.8
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF444 as an antibody target. Whether an autoantibody or antibody against ZNF444 could matter depends on whether native ZNF444 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF444 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF444 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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