ZSCAN26
Zinc finger and SCAN domain-containing protein 26
Also known as: SRE-ZBP, ZNF187, ZSC26_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q16670
- Gene
- ZSCAN26
- Ensembl
- ENSG00000197062
- Chromosome
- 6
- Canonical length
- 478 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
478 residues, UniProt reviewed canonical sequence.
>Q16670|ZSCAN26
1 MATALVSAHS LAPLNLKKEG LRVVREDHYS TWEQGFKLQG NSKGLGQEPL CKQFRQLRYE
61 ETTGPREALS RLRELCQQWL QPETHTKEQI LELLVLEQFL IILPKELQAR VQEHHPESRE
121 DVVVVLEDLQ LDLGETGQQD PDQPKKQKIL VEEMAPLKGV QEQQVRHECE VTKPEKEKGE
181 ETRIENGKLI VVTDSCGRVE SSGKISEPME AHNEGSNLER HQAKPKEKIE YKCSEREQRF
241 IQHLDLIEHA STHTGKKLCE SDVCQSSSLT GHKKVLSREK GHQCHECGKA FQRSSHLVRH
301 QKIHLGEKPY QCNECGKVFS QNAGLLEHLR IHTGEKPYLC IHCGKNFRRS SHLNRHQRIH
361 SQEEPCECKE CGKTFSQALL LTHHQRIHSH SKSHQCNECG KAFSLTSDLI RHHRIHTGEK
421 PFKCNICQKA FRLNSHLAQH VRIHNEEKPY QCSECGEAFR QRSGLFQHQR YHHKDKLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZSCAN26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- ovary: 25 nTPM
- retina: 25 nTPM
- cerebellum: 25 nTPM
- cervix: 20 nTPM
- endometrium: 18 nTPM
- seminal vesicle: 17 nTPM
Single-cell type
- medullary thymic epithelial cells: 2.4 nCPM
- cardiomyocytes: 1.4 nCPM
- thymic myoid cells: 1.4 nCPM
- gastric chief cells: 1.1 nCPM
- sertoli cells: 1.1 nCPM
- corticotrophs: 1 nCPM
Immune cell
- NK-cell: 23 nTPM
- naive B-cell: 20 nTPM
- naive CD4 T-cell: 19 nTPM
- MAIT T-cell: 19 nTPM
- basophil: 18 nTPM
- memory CD8 T-cell: 18 nTPM
Brain region
- cerebellum: 42 nTPM
- white matter: 36 nTPM
- cerebral cortex: 36 nTPM
- hypothalamus: 33 nTPM
- medulla oblongata: 31 nTPM
- thalamus: 30 nTPM
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZSCAN26 as an antibody target. Whether an autoantibody or antibody against ZSCAN26 could matter depends on whether native ZSCAN26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZSCAN26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZSCAN26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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