Seroatlas · Human Serome Atlas

ZSCAN12

Zinc finger and SCAN domain-containing protein 12

Also known as: dJ29K1.2, KIAA0426, ZFP96, ZNF29K1, ZNF305, ZNF96, ZSC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43309
Gene
ZSCAN12
Ensembl
ENSG00000158691
Chromosome
6
Canonical length
611 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>O43309|ZSCAN12
     1  MASTWAIQAH MDQDEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR QFCYQETSGP
    61  REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE ELQAWVQEQH PESGEEVVTV
   121  LEDLERELDE PGEQVSVHTG EQEMFLQETV RLRKEGEPSM SLQSMKAQPK YESPELESQQ
   181  EQVLDVETGN EYGNLKQEVS EEMEPHGKTS SKFENDMSKS ARCGETREPE EITEEPSACS
   241  REDKQPTCDE NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSHLI EHQRIHTGDR
   301  PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR LHTGEKHYHC
   361  NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI LTQHQGVHTG AKPYECNECG
   421  KAFVYNSSLV SHQEIHHKEK CYQCKECGKS FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ
   481  RTSLTEHQRI HTGERPYKCD KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL
   541  IQHQRIHTGE KPYQCDECGK AFRQRSDLSK HQRIHNRRGT YVCKECGKSF RQNSALTQHQ
   601  TIHKGEKSVS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
7.2 nTPM

Expression across tissuesHPA

Tissue

  • retina: 7.2 nTPM
  • breast: 5.9 nTPM
  • ovary: 5.5 nTPM
  • thyroid gland: 5.5 nTPM
  • thymus: 5.2 nTPM
  • lymph node: 4.9 nTPM

Single-cell type

  • early spermatids: 46 nCPM
  • late primary spermatocytes: 22 nCPM
  • adrenal medulla cells: 21 nCPM
  • sertoli cells: 18 nCPM
  • pdcs: 17 nCPM
  • cone photoreceptor cells: 17 nCPM

Immune cell

  • naive B-cell: 2.8 nTPM
  • basophil: 2.5 nTPM
  • NK-cell: 2 nTPM
  • memory B-cell: 1.9 nTPM
  • memory CD8 T-cell: 1.9 nTPM
  • naive CD4 T-cell: 1.9 nTPM

Brain region

  • cerebellum: 11 nTPM
  • cerebral cortex: 8.5 nTPM
  • hypothalamus: 8 nTPM
  • midbrain: 7.9 nTPM
  • basal ganglia: 7.4 nTPM
  • white matter: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
1.9

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN12 as an antibody target. Whether an autoantibody or antibody against ZSCAN12 could matter depends on whether native ZSCAN12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZSCAN12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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