Seroatlas · Human Serome Atlas

ZSCAN4

Zinc finger and SCAN domain-containing protein 4

Also known as: FLJ35105, ZNF494, ZSCA4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NAM6
Gene: ZSCAN4
Ensembl: ENSG00000180532
Chromosome: 19
Canonical length: 433 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q8NAM6|ZSCAN4
     1  MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ
    61  ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE
   121  DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD
   181  TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP
   241  YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV
   301  HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI
   361  IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK
   421  ITLPSVPSTP EAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

stomach: 2.4 nTPM
urinary bladder: 0.9 nTPM
skin: 0.8 nTPM
choroid plexus: 0.7 nTPM
placenta: 0.7 nTPM
prostate: 0.6 nTPM

Single-cell type

lymphatic endothelial cells: 2.8 nCPM
syncytiotrophoblasts: 2.6 nCPM
medullary thymic epithelial cells: 2.4 nCPM
papillary tip epithelial cells: 1.8 nCPM
fallopian tube ciliated cells: 1.6 nCPM
basal prostatic cells: 1.5 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 4.2 nTPM
cerebral cortex: 3.3 nTPM
white matter: 3.1 nTPM
basal ganglia: 3 nTPM
pons: 3 nTPM
hypothalamus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN4 as an antibody target. Whether an autoantibody or antibody against ZSCAN4 could matter depends on whether native ZSCAN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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