MZF1
Myeloid zinc finger 1
Also known as: MZF-1, MZF1_HUMAN, MZF1B, Zfp98, ZNF42, ZSCAN6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P28698
- Gene
- MZF1
- Ensembl
- ENSG00000099326
- Chromosome
- 19
- Canonical length
- 734 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
734 residues, UniProt reviewed canonical sequence.
>P28698|MZF1
1 MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP EAARLRFRCF RYEEATGPQE
61 ALAQLRELCR QWLRPEVRSK EQMLELLVLE QFLGALPPEI QARVQGQRPG SPEEAAALVD
121 GLRREPGGPR RWVTVQVQGQ EVLSEKMEPS SFQPLPETEP PTPEPGPKTP PRTMQESPLG
181 LQVKEESEVT EDSDFLESGP LAATQESVPT LLPEEAQRCG TVLDQIFPHS KTGPEGPSWR
241 EHPRALWHEE AGGIFSPGFA LQLGSISAGP GSVSPHLHVP WDLGMAGLSG QIQSPSREGG
301 FAHALLLPSD LRSEQDPTDE DPCRGVGPAL ITTRWRSPRG RSRGRPSTGG GVVRGGRCDV
361 CGKVFSQRSN LLRHQKIHTG ERPFVCSECG RSFSRSSHLL RHQLTHTEER PFVCGDCGQG
421 FVRSARLEEH RRVHTGEQPF RCAECGQSFR QRSNLLQHQR IHGDPPGPGA KPPAPPGAPE
481 PPGPFPCSEC RESFARRAVL LEHQAVHTGD KSFGCVECGE RFGRRSVLLQ HRRVHSGERP
541 FACAECGQSF RQRSNLTQHR RIHTGERPFA CAECGKAFRQ RPTLTQHLRV HTGEKPFACP
601 ECGQRFSQRL KLTRHQRTHT GEKPYHCGEC GLGFTQVSRL TEHQRIHTGE RPFACPECGQ
661 SFRQHANLTQ HRRIHTGERP YACPECGKAF RQRPTLTQHL RTHRREKPFA CQDCGRRFHQ
721 STKLIQHQRV HSAELocalizationUniProt · AlphaFold · HPA
Whether an antibody against MZF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 19 nTPM
- thyroid gland: 19 nTPM
- pituitary gland: 17 nTPM
- fallopian tube: 16 nTPM
- ovary: 16 nTPM
- prostate: 15 nTPM
Single-cell type
- respiratory ciliated cells: 93 nCPM
- tuft cells: 81 nCPM
- epicardial cells: 68 nCPM
- rod photoreceptor cells: 66 nCPM
- somatotrophs: 65 nCPM
- endometrial ciliated cells: 65 nCPM
Immune cell
- naive CD4 T-cell: 5.9 nTPM
- NK-cell: 5.3 nTPM
- naive CD8 T-cell: 3.8 nTPM
- memory CD4 T-cell: 3.6 nTPM
- MAIT T-cell: 3.2 nTPM
- naive B-cell: 2.7 nTPM
Brain region
- choroid plexus: 30 nTPM
- medulla oblongata: 21 nTPM
- cerebral cortex: 18 nTPM
- white matter: 18 nTPM
- midbrain: 18 nTPM
- cerebellum: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.08
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.26
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- protein homodimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MZF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MZF1 as an antibody target. Whether an autoantibody or antibody against MZF1 could matter depends on whether native MZF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MZF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MZF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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