Seroatlas · Human Serome Atlas

ZNF483

Zinc finger protein 483

Also known as: KIAA1962, ZKSCAN16, ZN483_HUMAN, ZSCAN48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF39
Gene: ZNF483
Ensembl: ENSG00000173258
Chromosome: 9
Canonical length: 744 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

744 residues, UniProt reviewed canonical sequence.

>Q8TF39|ZNF483
     1  MQAVVPLNKM TAISPEPQTL ASTEQNEVPR VVTSGEQEAI LRGNAADAES FRQRFRWFCY
    61  SEVAGPRKAL SQLWELCNQW LRPDIHTKEQ ILELLVFEQF LTILPGEIRI WVKSQHPESS
   121  EEVVTLIEDL TQMLEEKDPV SQDSTVSQEE NSKEDKMVTV CPNTESCESI TLKDVAVNFS
   181  RGEWKKLEPF QKELYKEVLL ENLRNLEFLD FPVSKLELIS QLKWVELPWL LEEVSKSSRL
   241  DESALDKIIE RCLRDDDHGL MEESQQYCGS SEEDHGNQGN SKGRVAQNKT LGSGSRGKKF
   301  DPDKSPFGHN FKETSDLIKH LRVYLRKKSR RYNESKKPFS FHSDLVLNRK EKTAGEKSRK
   361  SNDGGKVLSH SSALTEHQKR QKIHLGDRSQ KCSKCGIIFI RRSTLSRRKT PMCEKCRKDS
   421  CQEAALNKDE GNESGEKTHK CSKCGKAFGY SASLTKHRRI HTGEKPYMCN ECGKAFSDSS
   481  SLTPHHRTHS GEKPFKCDDC GKGFTLSAHL IKHQRIHTGE KPYKCKDCGR PFSDSSSLIQ
   541  HQRIHTGEKP YTCSNCGKSF SHSSSLSKHQ RIHTGEKPYK CGECGKAFRQ NSCLTRHQRI
   601  HTGEKPYLCN DCGMTFSHFT SVIYHQRLHS GEKPYKCNQC EKAFPTHSLL SRHQRIHTGV
   661  KPYKCKECGK SFSQSSSLNE HHRIHTGEKP YECNYCGATF SRSSILVEHL KIHTGRREYE
   721  CNECEKTFKS NSGLIRHRGF HSAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF483 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 20 nTPM
pituitary gland: 14 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 11 nTPM
retina: 11 nTPM
basal ganglia: 10 nTPM

Single-cell type

pituicytes/fscs: 340 nCPM
lactotrophs: 313 nCPM
somatotrophs: 287 nCPM
thyrotrophs: 277 nCPM
other brain neurons: 227 nCPM
corticotrophs: 222 nCPM

Immune cell

naive CD8 T-cell: 3.5 nTPM
naive CD4 T-cell: 3.2 nTPM
basophil: 2.9 nTPM
gdT-cell: 2.7 nTPM
memory CD4 T-cell: 1.7 nTPM
MAIT T-cell: 1.5 nTPM

Brain region

cerebellum: 184 nTPM
hypothalamus: 181 nTPM
basal ganglia: 144 nTPM
cerebral cortex: 139 nTPM
midbrain: 132 nTPM
white matter: 125 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF483.

Disease | ImmuneIEDB

Conditions an epitope on ZNF483 was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 2.4
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF483 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF483 as an antibody target. Whether an autoantibody or antibody against ZNF483 could matter depends on whether native ZNF483 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF483 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF483 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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