Seroatlas · Human Serome Atlas

ZSCAN10

Zinc finger and SCAN domain-containing protein 10

Also known as: ZNF206, ZSC10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SZ4
Gene: ZSCAN10
Ensembl: ENSG00000130182
Chromosome: 16
Canonical length: 780 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>Q96SZ4|ZSCAN10
     1  MLGESVPAAV EQEQLGEVKL EEEEAVSPED PRRPESRLRP EVAHQLFRCF QYQEDMGPRA
    61  SLSRLRELCG HWLRPALHTK KQILELLVLE QFLSVLPPHL LGRLQGQPLR DGEEVVLLLE
   121  GIHREPSHAG PLDFSCNAGK SCPRADVTLE EKGCASQVPS HSPKKELPAE EPSVLGPSDE
   181  PPRPQPRAAQ PAEPGQWRLP PSSKQPLSPG PQKTFQALQE SSPQGPSPWP EESSRDQELA
   241  AVLECLTFED VPENKAWPAH PLGFGSRTPD KEEFKQEEPK GAAWPTPILA ESQADSPGVP
   301  GEPCAQSLGR GAAASGPGED GSLLGSSEIL EVKVAEGVPE PNPELQFICA DCGVSFPQLS
   361  RLKAHQLRSH PAGRSFLCLC CGKSFGRSSI LKLHMRTHTD ERPHACHLCG HRFRQSSHLS
   421  KHLLTHSSEP AFLCAECGRG FQRRASLVQH LLAHAQDQKP PCAPESKAEA PPLTDVLCSH
   481  CGQSFQRRSS LKRHLRIHAR DKDRRSSEGS GSRRRDSDRR PFVCSDCGKA FRRSEHLVAH
   541  RRVHTGERPF SCQACGRSFT QSSQLVSHQR VHTGEKPYAC PQCGKRFVRR ASLARHLLTH
   601  GGPRPHHCTQ CGKSFGQTQD LARHQRSHTG EKPCRCSECG EGFSQSAHLA RHQRIHTGEK
   661  PHACDTCGHR FRNSSNLARH RRSHTGERPY SCQTCGRSFR RNAHLRRHLA THAEPGQEQA
   721  EPPQECVECG KSFSRSCNLL RHLLVHTGAR PYSCTQCGRS FSRNSHLLRH LRTHARETLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 0.4 nTPM
skin: 0.4 nTPM
bone marrow: 0.2 nTPM
cerebral cortex: 0.2 nTPM
pituitary gland: 0.1 nTPM
retina: 0.1 nTPM

Single-cell type

cytotrophoblasts: 2.4 nCPM
epicardial cells: 2.3 nCPM
migrating cytotrophoblasts: 2.2 nCPM
late spermatids: 1.1 nCPM
epididymal basal cells: 0.8 nCPM
differentiating spermatogonia: 0.7 nCPM

Immune cell

basophil: 0.5 nTPM
eosinophil: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

white matter: 5.9 nTPM
hypothalamus: 4.8 nTPM
cerebellum: 4.3 nTPM
cerebral cortex: 4.2 nTPM
thalamus: 3.8 nTPM
basal ganglia: 3.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZSCAN10.

Disease | AllUniProt

Conditions ZSCAN10 is implicated in, by any mechanism.

Otofacial neurodevelopmental syndrome (OFNS) MIM:620910

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 165 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Otofacial neurodevelopmental syndrome
Global developmental delay
Sensorineural hearing loss disorder
ZSCAN10 Deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN10 as an antibody target. Whether an autoantibody or antibody against ZSCAN10 could matter depends on whether native ZSCAN10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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