Seroatlas · Human Serome Atlas

ZNF213

Zinc finger protein 213

Also known as: CR53, ZKSCAN21, ZN213_HUMAN, ZSCAN53

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14771
Gene
ZNF213
Ensembl
ENSG00000085644
Chromosome
16
Canonical length
459 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear membrane,Vesicles,Cytosol

OverviewNCBI Gene

C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>O14771|ZNF213
     1  MAAPLEAQDQ APGEGEGLLI VKVEDSSWEQ ESAQHEDGRD SEACRQRFRQ FCYGDVHGPH
    61  EAFSQLWELC CRWLRPELRT KEQILELLVL EQFLTVLPGE IQGWVREQHP GSGEEAVALV
   121  EDLQKQPVKA WRQDVPSEEA EPEAAGRGSQ ATGPPPTVGA RRRPSVPQEQ HSHSAQPPAL
   181  LKEGRPGETT DTCFVSGVHG PVALGDIPFY FSREEWGTLD PAQRDLFWDI KRENSRNTTL
   241  GFGLKGQSEK SLLQEMVPVV PGQTGSDVTV SWSPEEAEAW ESENRPRAAL GPVVGARRGR
   301  PPTRRRQFRD LAAEKPHSCG QCGKRFRWGS DLARHQRTHT GEKPHKCPEC DKSFRSSSDL
   361  VRHQGVHTGE KPFSCSECGK SFSRSAYLAD HQRIHTGEKP FGCSDCGKSF SLRSYLLDHR
   421  RVHTGERPFG CGECDKSFKQ RAHLIAHQSL HAKMAQPVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF213 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • skeletal muscle: 10 nTPM
  • salivary gland: 9.8 nTPM
  • skin: 9.5 nTPM
  • cerebral cortex: 9 nTPM
  • hippocampal formation: 7.5 nTPM

Single-cell type

  • myonuclei: 177 nCPM
  • late spermatids: 110 nCPM
  • cardiomyocytes: 84 nCPM
  • myosatellite cells: 57 nCPM
  • fibro-adipogenic progenitors: 54 nCPM
  • rod photoreceptor cells: 44 nCPM

Immune cell

  • NK-cell: 1.7 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • naive B-cell: 1.5 nTPM
  • eosinophil: 1.3 nTPM
  • neutrophil: 1.3 nTPM
  • gdT-cell: 1.2 nTPM

Brain region

  • medulla oblongata: 25 nTPM
  • cerebral cortex: 23 nTPM
  • cerebellum: 22 nTPM
  • thalamus: 21 nTPM
  • white matter: 21 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
1.01
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF213 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF213 as an antibody target. Whether an autoantibody or antibody against ZNF213 could matter depends on whether native ZNF213 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF213 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF213 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF213. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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