Seroatlas · Human Serome Atlas

ZNF75D

Zinc finger protein 75D

Also known as: D8C6, ZKSCAN24, ZN75D_HUMAN, ZNF75, ZNF82, ZSCAN28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51815
Gene: ZNF75D
Ensembl: ENSG00000186376
Chromosome: X
Canonical length: 510 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>P51815|ZNF75D
     1  MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR HFWSFRYHEA
    61  TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI LPKETQNWVQ KHHPQNVKQA
   121  LVLVEFLQRE PDGTKNEVTA HELGKEAVLL GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY
   181  RVLQEQLGWN THKETQPVYE RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV
   241  AVYFSEEEWQ LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC
   301  EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK LMDLHGKGPT
   361  GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR RFRWSSDLNK HFMTHQGIKP
   421  YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS
   481  LCKRNFSRRS SLLRHQKLHR RREACLVSPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF75D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 14 nTPM
spleen: 13 nTPM
liver: 11 nTPM
prostate: 9.8 nTPM
pancreas: 9.5 nTPM
thyroid gland: 9 nTPM

Single-cell type

late spermatids: 476 nCPM
early spermatids: 199 nCPM
adrenal cortex cells: 128 nCPM
neutrophil progenitors: 107 nCPM
late primary spermatocytes: 96 nCPM
proximal tubule cells: 91 nCPM

Immune cell

T-reg: 3.4 nTPM
naive CD4 T-cell: 3.1 nTPM
naive CD8 T-cell: 2.8 nTPM
NK-cell: 2.8 nTPM
basophil: 2.7 nTPM
memory CD8 T-cell: 2.7 nTPM

Brain region

choroid plexus: 7.5 nTPM
hypothalamus: 7.5 nTPM
pons: 7 nTPM
white matter: 6.8 nTPM
thalamus: 6.6 nTPM
medulla oblongata: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF75D as an antibody target. Whether an autoantibody or antibody against ZNF75D could matter depends on whether native ZNF75D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF75D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF75D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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