Seroatlas · Human Serome Atlas

ZNF446

Zinc finger protein 446

Also known as: FLJ20626, ZKSCAN20, ZN446_HUMAN, ZSCAN52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWS9
Gene
ZNF446
Ensembl
ENSG00000083838
Chromosome
19
Canonical length
450 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9NWS9|ZNF446
     1  MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL CCQWLQPEAH
    61  SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL VEGLQHDPGQ LLGWITAHVL
   121  KQEVLPAAQK TEEPLGSPHP SGTVESPGEG PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS
   181  SPPLAAQSPE GNHGHQEPAS TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP
   241  PHQPEAQAQS ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
   301  APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH HRTHTSGPGV
   361  QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC GCSFSWKSQL VIHRKSHTGQ
   421  RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF446 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • testis: 14 nTPM
  • pituitary gland: 13 nTPM
  • cerebellum: 12 nTPM
  • ovary: 12 nTPM
  • prostate: 11 nTPM
  • cervix: 11 nTPM

Single-cell type

  • early primary spermatocytes: 46 nCPM
  • adrenal medulla cells: 32 nCPM
  • fallopian tube ciliated cells: 32 nCPM
  • respiratory ciliated cells: 26 nCPM
  • tuft cells: 23 nCPM
  • epididymal efferent duct ciliated cells: 19 nCPM

Immune cell

  • non-classical monocyte: 5.3 nTPM
  • memory CD4 T-cell: 3.3 nTPM
  • intermediate monocyte: 3.1 nTPM
  • myeloid DC: 3 nTPM
  • basophil: 2.9 nTPM
  • naive CD8 T-cell: 2.9 nTPM

Brain region

  • cerebellum: 13 nTPM
  • medulla oblongata: 12 nTPM
  • white matter: 11 nTPM
  • cerebral cortex: 11 nTPM
  • amygdala: 10 nTPM
  • hypothalamus: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF446.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
-0.58
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF446 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF446 as an antibody target. Whether an autoantibody or antibody against ZNF446 could matter depends on whether native ZNF446 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF446 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF446 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF446. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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