Seroatlas · Human Serome Atlas

ZKSCAN8

Zinc finger protein with KRAB and SCAN domains 8

Also known as: LD5-1, ZKSC8_HUMAN, ZNF192, ZSCAN40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15776
Gene
ZKSCAN8
Ensembl
ENSG00000198315
Chromosome
6
Canonical length
578 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q15776|ZKSCAN8
     1  MAEESRKPSA PSPPDQTPEE DLVIVKVEED HGWDQESSLH ESNPLGQEVF RLRFRQLRYQ
    61  ETLGPREALI QLRALCHQWL RPDLNTKEQI LELLVLEQFL TILPEELQTL VKEHQLENGE
   121  EVVTLLEDLE RQIDILGRPV SARVHGHRVL WEEVVHSASA PEPPNTQLQS EATQHKSPVP
   181  QESQERAMST SQSPTRSQKG SSGDQEMTAT LLTAGFQTLE KIEDMAVSLI REEWLLDPSQ
   241  KDLCRDNRPE NFRNMFSLGG ETRSENRELA SKQVISTGIQ PHGETAAKCN GDVIRGLEHE
   301  EARDLLGRLE RQRGNPTQER RHKCDECGKS FAQSSGLVRH WRIHTGEKPY QCNVCGKAFS
   361  YRSALLSHQD IHNKVKRYHC KECGKAFSQN TGLILHQRIH TGEKPYQCNQ CGKAFSQSAG
   421  LILHQRIHSG ERPYECNECG KAFSHSSHLI GHQRIHTGEK PYECDECGKT FRRSSHLIGH
   481  QRSHTGEKPY KCNECGRAFS QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH
   541  TGEKPYQCNE CGKAFIQRSS LIRHQRIHSG EKSESISV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZKSCAN8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • retina: 16 nTPM
  • endometrium: 15 nTPM
  • bone marrow: 14 nTPM
  • ovary: 14 nTPM
  • epididymis: 13 nTPM
  • thymus: 12 nTPM

Single-cell type

  • myonuclei: 35 nCPM
  • cardiomyocytes: 34 nCPM
  • choroid plexus epithelial cells: 32 nCPM
  • somatotrophs: 28 nCPM
  • oligodendrocyte progenitor cells: 27 nCPM
  • hematopoietic stem cells: 26 nCPM

Immune cell

  • basophil: 2.2 nTPM
  • non-classical monocyte: 2.2 nTPM
  • naive B-cell: 1.7 nTPM
  • intermediate monocyte: 1.2 nTPM
  • MAIT T-cell: 1.1 nTPM
  • NK-cell: 1.1 nTPM

Brain region

  • white matter: 28 nTPM
  • cerebellum: 27 nTPM
  • choroid plexus: 25 nTPM
  • medulla oblongata: 22 nTPM
  • basal ganglia: 22 nTPM
  • cerebral cortex: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
1.09
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZKSCAN8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZKSCAN8 as an antibody target. Whether an autoantibody or antibody against ZKSCAN8 could matter depends on whether native ZKSCAN8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZKSCAN8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZKSCAN8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZKSCAN8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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