Seroatlas · Human Serome Atlas

ZSCAN30

Zinc finger and SCAN domain-containing protein 30

Also known as: ZNF397OS, ZNF917, ZSC30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86W11
Gene: ZSCAN30
Ensembl: ENSG00000186814
Chromosome: 18
Canonical length: 494 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q86W11|ZSCAN30
     1  MSGEATVLAY HAPEEQEGLL VVKVEEENYV LDQDFGLQEN PWSQEVFRQK FRQFSYSDST
    61  GPREALSRLR ELCCQWLRPE VHSKEQILEL LMLEQFLAIL PEELQAWLRE HRPENGEEAV
   121  TMLEELEKEL EEPRQQDTTH GQEMFWQEMT STGALKSLSL NSPVQPLENQ CKTETQESQA
   181  FQERDGRMVA GKVLMAKQEI VECVASAAMI SPGKLPGETH SQRIAEEALG GLDNSKKQKG
   241  NAAGNKISQL PSQDRHFSLA TFNRRIPTEH SVLESHESEG SFSMNSNDIT QQSVDTREKL
   301  YECFDCGKAF CQSSKLIRHQ RIHTGERPYA CKECGKAFSL SSDLVRHQRI HSGEKPYECC
   361  ECGKAFRGSS ELIRHRRIHT GEKPYECGEC GKAFSRSSAL IQHKKIHTGD KSYECIACGK
   421  AFGRSSILIE HQRIHTGEKP YECNECGKSF NQSSALTQHQ RIHTGEKPYE CSECRKTFRH
   481  RSGLMQHQRT HTRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

retina: 25 nTPM
cerebellum: 25 nTPM
heart muscle: 17 nTPM
pituitary gland: 16 nTPM
skeletal muscle: 16 nTPM
thyroid gland: 14 nTPM

Single-cell type

myonuclei: 130 nCPM
cardiomyocytes: 80 nCPM
oligodendrocytes: 61 nCPM
lactotrophs: 57 nCPM
choroid plexus epithelial cells: 54 nCPM
somatotrophs: 51 nCPM

Immune cell

naive B-cell: 3.3 nTPM
naive CD8 T-cell: 2.6 nTPM
plasmacytoid DC: 2.6 nTPM
memory B-cell: 2.5 nTPM
eosinophil: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM

Brain region

white matter: 86 nTPM
cerebellum: 84 nTPM
hypothalamus: 66 nTPM
cerebral cortex: 64 nTPM
basal ganglia: 63 nTPM
thalamus: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN30 as an antibody target. Whether an autoantibody or antibody against ZSCAN30 could matter depends on whether native ZSCAN30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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