Seroatlas · Human Serome Atlas

ZFP69B

Zinc finger protein 69 homolog B

Also known as: FLJ34293, ZF69B_HUMAN, ZKSCAN23B, ZNF643, ZSCAN54B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJL9
Gene: ZFP69B
Ensembl: ENSG00000187801
Chromosome: 1
Canonical length: 534 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q9UJL9|ZFP69B
     1  MLQQLLITLP TEASTWVKLR HPKAATERVA LWEDVTKMFK AEALLSQDAD ETQGESLESR
    61  VTLGSLTAES QELLTFKDVS VDFTQEEWGQ LAPAHRNLYR EVMLENYGNL VSVGCQLSKP
   121  GVISQLEKGE EPWLMERDIS GVPSSDLKSK TKTKESALQN DISWEELHCG LMMERFTKGS
   181  SMYSTLGRIS KCNKLESQQE NQRMGKGQIP LMCKKTFTQE RGQESNRFEK RINVKSEVMP
   241  GPIGLPRKRD RKYDTPGKRS RYNIDLVNHS RSYTKMKTFE CNICEKIFKQ LIHLTEHMRI
   301  HTGEKPFRCK ECGKAFSQSS SLIPHQRIHT GEKPYECKEC GKTFRHPSSL TQHVRIHTGE
   361  KPYECRVCEK AFSQSIGLIQ HLRTHVREKP FTCKDCGKAF FQIRHLRQHE IIHTGVKPYI
   421  CNVCSKTFSH STYLTQHQRT HTGERPYKCK ECGKAFSQRI HLSIHQRVHT GVKPYECSHC
   481  GKAFRHDSSF AKHQRIHTGE KPYDCNECGK AFSCSSSLIR HCKTHLRNTF SNVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP69B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 2.1 nTPM
thymus: 1.8 nTPM
tonsil: 1.8 nTPM
appendix: 1.6 nTPM
retina: 1.4 nTPM
endometrium: 1.3 nTPM

Single-cell type

brain inhibitory neurons: 13 nCPM
brain excitatory neurons: 9.1 nCPM
oligodendrocyte progenitor cells: 8.3 nCPM
differentiating spermatogonia: 8.1 nCPM
neutrophils: 7.8 nCPM
plasma cells: 7.3 nCPM

Immune cell

T-reg: 1.5 nTPM
MAIT T-cell: 1.2 nTPM
naive CD4 T-cell: 1.2 nTPM
naive CD8 T-cell: 1 nTPM
gdT-cell: 0.9 nTPM
intermediate monocyte: 0.7 nTPM

Brain region

cerebral cortex: 10 nTPM
amygdala: 7.8 nTPM
basal ganglia: 7.1 nTPM
hippocampal formation: 7 nTPM
white matter: 6.7 nTPM
pons: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP69B as an antibody target. Whether an autoantibody or antibody against ZFP69B could matter depends on whether native ZFP69B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP69B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP69B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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